803640-64-4

Basic information

• Product Name: 2-(4-methoxyphenyl)quinoline-4-carbonyl chloride
• Synonyms: 4-quinolinecarbonyl chloride, 2-(4-methoxyphenyl)-;2-(4-methoxyphenyl)-4-quinolinecarbonyl chloride;2-(4-methoxyphenyl)quinoline-4-carbonyl chloride
• CAS NO: 803640-64-4
• Molecular Formula: C17H12ClNO2
• Molecular Weight: 297.73568
• Mol File: 803640-64-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-methoxyphenyl)quinoline-4-carbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)quinoline-4-carbonyl chloride(803640-64-4)
• EPA Substance Registry System: 2-(4-methoxyphenyl)quinoline-4-carbonyl chloride(803640-64-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 803640-64-4(Hazardous Substances Data)

Usage

Structure

A carbonyl chloride derivative of 2-(4-methoxyphenyl)quinoline-4-carboxylic acid

Reactivity

Reactive intermediate commonly used in organic synthesis

Applications

Production of pharmaceuticals and agrochemicals

Versatility

Can be used to create various derivatives with different functional groups

Value

Valuable tool in the development of new chemical compounds for a wide range of applications

Upstream product

• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 4364-02-7 2-(4-methoxyphenyl)quinoline-4-carboxylic acid 
• 42366-35-8 hydroxyimino-N-phenylacetamide 
• 91-56-5 indole-2,3-dione 
• 62-53-3 aniline 

Downstream Products

• 858474-14-3 C₂₂H₂₄N₂O₂*ClH 
• 858474-14-3 C₂₂H₂₄N₂O₂*ClH 

Relevant articles and documents

Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity

SIRT6 activation is thought to be a promising target for the treatment of many diseases, particularly cancer. Herein, we report the discovery of a series of new small-molecule SIRT6 activators. Structure-activity relationship analyses led to the identific

Design, synthesis and antitumour activity of bisquinoline derivatives connected by 4-oxy-3-fluoroaniline moiety

A series of novel bisquinoline derivatives connected by a 4-oxy-3-fluoroaniline moiety were synthesized and evaluated for their in vitro antitumour activities against a panel of five cancer cell lines (H460, HT-29, MKN-45, U87MG, and SMMC-7721). Most of compounds tested showed a potent activity and high selectivity towards the H460 and MKN-45 cell lines. Among the compounds tested, six (15d, 15e, 15m, 15n, 16a, and 16i) were further examined for their c-Met kinase activity; the compounds showed high efficacy with IC 50 values in the single-digit nM range. An analysis of structure-activity relationships indicated that an unsubstituted or a halogen-substituted phenyl ring on the 2-arylquinoline-4-carboxamide moiety was favourable for antitumour activity.