803706-48-1Relevant academic research and scientific papers
Discovery of potent and orally active MTP inhibitors as potential anti-obesity agents
Li, Jin,Bertinato, Peter,Cheng, Hengmiao,Cole, Bridget M.,Bronk, Brian S.,Jaynes, Burton H.,Hickman, Anne,Haven, Michelle L.,Kolosko, Nicole L.,Barry, Chris J.,Manion, Tara B.
, p. 3039 - 3042 (2008/09/20)
We have successfully identified a number of novel MTP inhibitors with single digit nanomolar potency. Analogues 10aq and 10dq demonstrated in vivo efficacy in a murine gut retention assay.
Inhibitors designed for presenilin 1 by means of aspartic acid activation: Preliminary communication
Larbig, Gregor,Zall, Andrea,Schmidt, Boris
, p. 2334 - 2340 (2007/10/03)
γ-Secretase, a multiprotein aspartic protease crucial to Alzheimer's dementia, is not available for NMR experiments and has, so far, escaped crystallization. A positional scan of the aspartic protease by reactive probes may provide the necessary structura
