803712-79-0 Usage
Description
Obatoclax (803712-79-0) is a novel Bcl-2 homology domain-3 (BH3) mimetic.1?Inhibits primary acute myeloid leukemia (AML) progenitor cell proliferation (IC50=0.18 μM) and induces apoptosis in primary AML cells (IC50= 3.6 μM).2?Obatoclax synergizes with other agents such as chloroquine3?and cytarabine4?in cytotoxicity against a variety of cancer cells.
Chemical Properties
Red powder
Uses
Different sources of media describe the Uses of 803712-79-0 differently. You can refer to the following data:
1. Obatoclax Mesylate is a novel Bcl-2 homology domain-3 (BH3) mimetic.
2. Obatoclax (GX15-070) is an inhibitor of Bcl-2 with Ki of 0.22 μM.
References
1) Chonghaile and Letai (2008),?Mimicking the BH3 domain to kill cancer cells; Oncogene,?27?S149
2) Konopleva?et al. (2008),?Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax); Cancer Res.,?68?3413
3) Wang?et al. (2014),?Combination of chloroquine and GX15-070 (obatoclax) results in synergistic cytotoxicity against pancreatic cancer cells; Oncol. Rep.,?32?2789
4) Xie?et al. (2015),?Obatoclax potentiates the cytotoxic effect of cytarabine on acute myeloid leukemia cells by enhancing DNA damage; Mol. Oncol.,?9?409
Check Digit Verification of cas no
The CAS Registry Mumber 803712-79-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,0,3,7,1 and 2 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 803712-79:
(8*8)+(7*0)+(6*3)+(5*7)+(4*1)+(3*2)+(2*7)+(1*9)=150
150 % 10 = 0
So 803712-79-0 is a valid CAS Registry Number.
InChI:InChI=1/C20H19N3O.CH4O3S/c1-12-8-13(2)21-16(12)10-19-20(24-3)11-18(23-19)17-9-14-6-4-5-7-15(14)22-17;1-5(2,3)4/h4-11,21-22H,1-3H3;1H3,(H,2,3,4)/b19-10-;