803712-90-5Relevant academic research and scientific papers
An investigation into the tether length and substitution pattern of arene-substituted complexes for asymmetric transfer hydrogenation of ketones
Cheung, Fung K.,Lin, Changxue,Minissi, Franco,Criville, Adriana Lorente,Graham, Mark A.,Fox, David J.,Wills, Martin
, p. 4659 - 4662 (2007)
(Figure Presented) A series of Ru(II) catalysts were prepared and tested in the asymmetric transfer hydrogenation of ketones. The catalyst containing a "4-carbon" tether gave the fastest rates of ketone reduction. This is due to both increased rate of reg
A new class of modular P,N-ligand library for asymmetric Pd-catalyzed allylic substitution reactions: A study of the key Pd-π- allyl intermediates
Mazuela, Javier,Paptchikhine, Alexander,Tolstoy, Paeivi,Pamies, Oscar,Dieguez, Montserrat,Andersson, Pher G.
body text, p. 620 - 638 (2010/06/12)
A new class of modular P,N-ligand libary has been Synthesized and screened in the pd-catalyzed allylic substitution reaction of several substrate types. These series of ligands can be prepared efficiently from easily accessible hydroxyle - oxazale/ thiazale de-rivatives. modular nature enables the bridge, the substituents at teh hetro cyclic ring and in the alkyl back bone chain, the configuration of the ligand backbone, and the substituents/configurations in the biaryl phosphite moiety to be easily and systematically varied. By carefully selecting the ligand components, therefore, high regio- and enantioselectivities (ee values up to 96%) and good activities are achieved in a broad range of mono-, di-, and trisubstituted linear hindered and unhindered substrates and cyclic substrates. The NMR spectroscopic and DFT studies on the Pdπ-allyl intermediates provide a deeper understanding of the effect of ligand parameters on the origin of enantioselectivity.
Rationally designed ligands for asymmetric iridium-catalyzed hydrogenation of olefins
Kaellstroem, Klas,Hedberg, Christian,Brandt, Peter,Bayer, Annette,Andersson, Pher G.
, p. 14308 - 14309 (2007/10/03)
A new class of chiral N,P-ligands for the Ir-catalyzed asymmetric hydrogenation of aryl alkenes has been developed. These new ligands proved to be highly efficient and tolerates a broad range of substrates. The enantiomeric excesses are in the range of the best ever reported. The results can be rationalized with the proposed selectivity model. Copyright
