80385-43-9

Upstream product

• 1552-91-6 cyclohexylideneacetic acid 
• 14399-63-4 2-(1-hydroxycyclohexyl)acetic acid 
• 1552-92-7 ethyl cyclohexylideneacetate 
• 7719-09-7 thionyl chloride 
• 108-94-1 cyclohexanone 

Downstream Products

• 874-68-0 1-cyclohexylidene-2-propanone 
• 1017-23-8 2-(cyclohex-1-en-1-yl)-1-phenylethan-1-one 
• 219702-81-5 3-Cyclohexylidene-1-furan-3-yl-1-(toluene-4-sulfonyl)-propan-2-one 
• 219702-91-7 3-Cyclohexylidene-1-thiophen-3-yl-1-(toluene-4-sulfonyl)-propan-2-one 
• 854724-19-9 3-<2-Dimethylamino-aethyl>-cyclohexen-(1) 
• 65378-67-8 N,N-dimethylcyclohexylideneacetamide 
• 1552-92-7 ethyl cyclohexylideneacetate 
• 1334472-83-1 2-((1S,2S)-2-(1,2-bis(tert-butoxycarbonyl)hydrazinyl)cyclohexyl)acetic acid 
• 81096-49-3 2-(cyclohex-1-en-1-yl)-1-phenylpropan-1-one 
• 87493-35-4 cyclohex-1-enyl-acetic acid o-toluidide 
• 859174-40-6 (1-ethoxy-cyclohexyl)-acetic acid ethyl ester 
• 1481-99-8 spiro[5.5]undecane-2,4-dione 
• 4709-59-5 ethyl 2-(1-cyclohexenyl)acetate 

Relevant academic research and scientific papers

INTRAMOLECULAR RING CLOSURE OF α,β-UNSATURATED 3-ACYLINDOLES

A number of unsaturated 3-acylindoles were prepared and annulated ( with HCl or NaCl-AlCl3 ) to 3,4-dihydrocyclopentindol-1(2H)-ones or 1,2,3,9-tetrahydro-4H-carbazol-4-ones depending on the structure of the substrate and/or the reaction conditions.

Intramolecular Nitrofuran Diels-Alder Reactions: Extremely Substituent-Tolerant Cycloadditions via Asynchronous Transition States

Nitrofurans undergo intramolecular Diels-Alder reactions with tethered electron-poor dienophiles more rapidly and in higher yield than non-nitrated furans. Computational studies indicate that increased stabilization of a partial positive charge on the nitro-substituted carbon in both transition state and product is the driving force for these reactions. Frontier molecular orbital energy differences indicate a switch from normal to inverse electron demand upon nitration. There does not appear to be a contribution from any differences in aromatic stabilization energy between furans and nitrofurans. Calculations show that the nitrofuran reactions proceed via a highly asynchronous transition state allowing easier bond formation between two sterically hindered carbons.

Pd-Catalyzed α-Selective C-H Functionalization of Olefins: En Route to 4-Imino-β-Lactams

Pd-catalyzed α-olefinic C-H activation of simple α,β-unsaturated olefins has been developed. 4-imino-β-lactam derivatives were readily synthesized via activation of α-olefinic C-H bonds with excellent cis stereoselectivity. A wide range of heterocycles at the β-position are compatible with this reaction. The product of 4-imino-β-lactam derivatives can be readily converted to 2-aminoquinoline which exists extensively in pharmaceutical drugs and natural products.

Diastereoselective synthesis of the model insect antifeedants related to azadiradione and epoxyazadiradione based on intramolecular insertion of α- aryl-α-diazoketones

A new practical and stereoselective method for the synthesis of the model insect antifeedant CDE fragment of azadiradione and epoxyazadiradione, based on intramolecular insertion of α-aryl-α-diazoketones, has been developed. The procedure can be applied to complex systems. A short SAR study is reported.

Thermal Conversion of Phorone into Isophorone via (Trimethylsilyl)oxyhexatriene (SOH) Cyclization

Heating of 3-Z-4-(trimethylsilyl)oxy-2,6-dimethylhepta-1,3,5-triene, readily available from phorone (LDA; TMSCl), at 220 deg C caused isomerization and cyclization to afford isophorone after deprotection.