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8-Methoxy-d3 Psoralen is a labeled analogue of 8-Methoxy Psoralen (M260795), a naturally occurring analog of Psoralen (P839800). It is characterized by the presence of a deuterium atom (D3), which allows for the study of its pharmacokinetics and metabolism without any isotopic effect on these properties.
Used in Pharmaceutical Industry:
8-Methoxy-d3 Psoralen is used as a therapeutic agent for the treatment of skin conditions such as psoriasis and mycosis fungoides. It is particularly effective due to its ability to intercalate into DNA, leading to the inhibition of DNA synthesis and repair, which is crucial for the management of these conditions.
8-Methoxy-d3 Psoralen is also used as a research tool in pharmacokinetic studies. Its deuterium labeling allows researchers to track and analyze its metabolism and distribution within the body, providing valuable insights into the behavior of similar compounds and aiding in the development of new therapeutic agents.

80386-99-8

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80386-99-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 80386-99-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,3,8 and 6 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 80386-99:
(7*8)+(6*0)+(5*3)+(4*8)+(3*6)+(2*9)+(1*9)=148
148 % 10 = 8
So 80386-99-8 is a valid CAS Registry Number.

80386-99-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 9-[(<sup>2</sup>H<sub>3</sub>)Methyloxy]-7H-furo[3,2-g]chromen-7-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:80386-99-8 SDS

80386-99-8Downstream Products

80386-99-8Relevant academic research and scientific papers

Trideuteromethylation Enabled by a Sulfoxonium Metathesis Reaction

Shen, Zuyuan,Zhang, Shilei,Geng, Huihui,Wang, Jiarui,Zhang, Xinyu,Zhou, Anqi,Yao, Cheng,Chen, Xiaobei,Wang, Wei

, p. 448 - 452 (2019)

A conceptually novel sulfoxonium metathesis reaction between TMSOI and cost-effective DMSO-d6 is developed for the efficient generation of a new trideuteromethylation reagent TDMSOI. The new reagent TDMSOI is produced highly efficiently by simply heating a mixture of TMSOI and DMSO-d6 and directly used for subsequent trideuteromethylation in a "one-pot" operation. The preparative power of the new versatile reagent and the "one-pot" protocol is demonstrated by its use to install the ?CD3 moiety into broad functionalities including phenols, thiophenols, acidic amines, and enolizable methylene units in high yield and at a useful level of deuteration (>87% D).

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