80396-04-9Relevant academic research and scientific papers
USE OF ENDOCANNABINOID-LIKE COMPOUNDS FOR TREATING CNS DEGENERATIVE DISORDERS
-
Paragraph 0045-0047, (2017/09/12)
no abstract published
Synthesis and biological evaluation of macamides derivatives as potent inhibitors of breast cancer cell MCF-7
Liang, Xiao Xia,Xiong, Cheng,He, Min,He, Changliang,Yin, Zhongqiong
, p. 489 - 494 (2016/07/19)
A series of macamides (1-4) and their synthetic analogs (5-14) were synthesized and evaluated for in vitro inhibitory activities against breast cancer cell MCF-7. The results of bioactive assay showed that two of the macamides (compound 1 and 4) and one synthetic analog (compound 5) displayed comparable inhibitory activities against MCF-7 cell line, with IC50 values of 29.6, 36.2 and 27.2 μM, respectively.
Synthesis and identification of small molecules that potently induce apoptosis in melanoma cells through G1 cell cycle arrest
Dothager, Robin S.,Putt, Karson S.,Allen, Brittany J.,Leslie, Benjamin J.,Nesterenko, Vitaliy,Hergenrother, Paul J.
, p. 8686 - 8696 (2007/10/03)
Late-stage malignant melanoma is a cancer that is refractory to current chemotherapeutic treatments. The average survival time for patients with such a diagnosis is 6 months. In general, the vast majority of anticancer drugs operate through induction of cell cycle arrest and cell death in either the DNA synthesis (S) or mitosis (M) phase of the cell cycle. Unfortunately, the same mechanisms that melanocytes possess to protect cells from DNA damage often confer resistance to drugs that derive their toxicity from S or M phase arrest. Described herein is the synthesis of a combinatorial library of potential proapoptotic agents and the subsequent identification of a class of small molecules (triphenylmethylamides, TPMAs) that arrest the growth of melanoma cells in the G1 phase of the cell cycle. Several of these TPMAs are quite potent inducers of apoptotic death in melanoma cell lines (IC50 ～ 0.5 μM), and importantly, some TPMAs are comparatively nontoxic to normal cells isolated from the bone marrow of healthy donors. Furthermore, the TPMAs were found to dramatically reduce the level of active nuclear factor κ-B (NFκB) in the cell; NFκB is known to be constitutively active in melanoma, and this activity is critical for the proliferation of melanoma cells and their evasion of apoptosis. Compounds that reduce the level of NFκB and arrest cells in the G1 phase of the cell cycle can provide insights into the biology of melanoma and may be effective antimelanoma agents.
Solid-supported chloro[1,3,5]triazine. A versatile new synthetic auxiliary for the synthesis of amide libraries
Masala, Simonetta,Taddei, Maurizio
, p. 1355 - 1357 (2008/02/09)
(equation presented) 2,4,6-Trichloro[1,3,5]triazine was loaded on different types of NH2-functionalized resins to give a new supported reagent. The best results, in term of yields products, were obtained using the chlorotriazine linked to a polystyrene-poly(ethylene glycol) resin. This reagent was employed for the solution-phase synthesis of different amides and dipeptides.
Chiral Aggregation Phenomena. 3. Chiral Discrimination in the Monolayer Packing of N-(α-Methylbenzyl)stearamides on Aqueous Acid Subphases: Thermodynamic Behavior
Arnett, Edward M.,Chao, Jean,Kinzig, Barbara J.,Stewart, Martin V.,Thompson, Orlean,Verbiar, Robert J.
, p. 389 - 400 (2007/10/02)
The study of monolayers at the air-liquid interface offers unusual opportunities to investigate the effects of stereochemical factors in organized systems.As a first step toward developing this field, we have examined some surface properties of N-(α-methy
