804-63-7 Usage
Chemical Properties
White powder
Uses
Quinine, an extremely bitter substance, has been used by millions of malaria sufferers. In recent times, it has been employed successfully to treat chloroquine-resistant strains of P. falciparum but it frequently fails to provide a complete cure of the infection.
Definition
ChEBI: A organic sulfate salt obtained from guanethidine and sulfuric acid in a 2:1 ratio.
World Health Organization (WHO)
Quinine is an important drug in the treatment of multi- drugresistant
forms of malaria. Its use in nocturnal leg muscle cramps, a benign and
self-limiting condition, is connected with unjustified risks. Quinine is listed in the
WHO Model List of Essential Drugs for treatment of malaria.
Safety Profile
Human poison by ingestion. Human systemic effects by ingestion: acuity changes, blood agranulocytosis, fibrous hepatitis, flaccid paralysis without anesthesia, motor activity changes, mydriasis (pupillary dilation), nausea or vomiting, tinnitus, visual field changes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of SO, and NO,. See also QUININE.
Purification Methods
Crystallise it from water and dry it at 110o. [Beilstein 23 H 522, 23 I 168, 23 II 420, 23 III/IV 3269, 23 V 396.]
Check Digit Verification of cas no
The CAS Registry Mumber 804-63-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,0 and 4 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 804-63:
(5*8)+(4*0)+(3*4)+(2*6)+(1*3)=67
67 % 10 = 7
So 804-63-7 is a valid CAS Registry Number.
InChI:InChI=1/2C20H24N2O2.H2O4S/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4)/t2*13-,14-,19-,20+;/m00./s1
