80428-39-3

Upstream product

• 80428-34-8 1-[3-(4-acetamido-2-methoxyphenoxy)-n-propyl]-4-phenyl-piperazine 

Downstream Products

• 80428-75-7 1-[3-(4-n-octanamido-2-methoxyphenoxy)-n-propyl]-4-phenyl-piperazine 
• 80428-60-0 1-[3-(4-pentanamido-2-methoxyphenoxy)-n-propyl]-4-phenyl-piperazine 
• 80428-77-9 1-{3-[4-(3-methylureido)-2-methoxyphenoxy]-n-propyl}-4-phenyl-piperazine 

Relevant academic research and scientific papers

N-Aryl-N-phenoxy-alkyl-piperazine compounds useful in decreasing intracranial pressure

A piperazine derivative of the formula: STR1 wherein R1 is hydrogen, alkyl (C1-8), alkyl (C1-4)-sulfonyl or an acyl group of the formula: R3 CO--(wherein R3 is hydrogen, alkyl (C1-7), halogenoalkyl (C1-4), alkoxy (C1-4)-carbonyl-alkyl (C1-4), cycloalkyl (C3-6), alkenyl (C2-5), alkoxy (C1-4), amino, alkyl (C1-4)-amino or anilino), R2 is hydrogen, alkyl (C1-4), alkoxy (C1-4)-carbonyl-alkyl (C1-4), carboxy-alkyl (C1-4), alkenyl (C2-5) or alkyl (C1-4)-sulfonyl, or R1 and R2 are combined together to form succinyl group, Ring A is phenyl, alkyl (C1-4)-phenyl or halogenophenyl, and n is an integer of 2 to 6, or a pharmaceutically acceptable acid addition salt thereof. The piperazine derivative (I) has an intracranial pressure-lowering activity. Said derivative also has a depressing effect on central nervous system.