(-)-(1S,2R,3R,4S)-3,4-Dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenz(a)anthracene, also known as benzo(a)pyrene dihydrodiol epoxide, is a highly toxic and carcinogenic chemical compound. It is a derivative of the polycyclic aromatic hydrocarbon benzo(a)pyrene, which is found in tobacco smoke, automobile exhaust, and grilled or charred foods. (-)-(1S,2R,3R,4S)-3,4-Dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenz(a)ant hracene activates the aryl hydrocarbon receptor and is metabolized by cytochrome P450 enzymes to form reactive intermediates that can bind to and damage DNA, leading to mutations and ultimately, cancer. Used in Environmental Monitoring: (-)-(1S,2R,3R,4S)-3,4-Dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenz(a)anthracene is used as a biomarker for environmental pollution and public health risk assessment. Its presence in air, water, and soil samples indicates exposure to carcinogenic compounds and helps in evaluating the level of environmental contamination. Used in Cancer Research: In the field of cancer research, (-)-(1S,2R,3R,4S)-3,4-Dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenz(a)anthracene is used as a model compound to study the mechanisms of carcinogenesis and the effects of exposure to environmental pollutants on DNA damage and mutations. This helps in understanding the molecular basis of cancer development and identifying potential therapeutic targets. Used in Toxicology Studies: (-)-(1S,2R,3R,4S)-3,4-Dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenz(a)anthracene is used in toxicology studies to investigate the toxic effects of exposure to polycyclic aromatic hydrocarbons and their metabolites. This aids in the development of strategies for risk assessment, prevention, and mitigation of the harmful effects of these environmental pollutants. Used in Regulatory Compliance: (-)-(1S,2R,3R,4S)-3,4-Dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenz(a)anthracene is used in regulatory compliance to set safety standards and guidelines for exposure limits to carcinogenic compounds in various industries, such as tobacco manufacturing, automotive, and food processing. This helps in reducing the risk of cancer and other health issues associated with exposure to these harmful chemicals.
The CAS Registry Mumber 80433-81-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,4,3 and 3 respectively; the second part has 2 digits, 8 and 1 respectively. Calculate Digit Verification of CAS Registry Number 80433-81: (7*8)+(6*0)+(5*4)+(4*3)+(3*3)+(2*8)+(1*1)=114 114 % 10 = 4 So 80433-81-4 is a valid CAS Registry Number.
80433-81-4Relevant academic research and scientific papers
Synthesis of the Enantiomeric Bay-Region Diol Epoxides of Benzanthracene and Chrysene
Yagi, Haruhiko,Vyas, Kamlesh P.,Tada, Masao,Thakker, Dhiren R.,Jerina, Donald M.
, p. 1110 - 1117 (2007/10/02)
Both trans-3,4-dihydroxy-3,4-dihydrobenzanthracene and trans-1,2-dihydroxy-1,2-dihydrochrysene are known proximate carcinogens of their respective hydrocarbons.The present study describes the synthesis of their (+)- and (-)-enantiomers as well as the d
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