80434-77-1

Upstream product

• 14236-04-5 N-methyl-N-(oxiran-2-ylmethyl)aniline 
• 100-61-8 N-methylaniline 
• 82585-86-2 ethyl 6-amino-4-<<2-hydroxy-3-(N-methyl-N-phenylamino)propyl>amino>-5-nitro-2-pyridinecarbamate 
• 82585-29-3 2-[2-[(E)-Hydroxyimino]-3-(methyl-phenyl-amino)-propyl]-isoindole-1,3-dione 
• 82585-27-1 1-amino-3-(N-methyl-N-phenylamino)propanone oxime 
• 6506-86-1 ethyl (6-amino-4-chloro-5-nitropyridin-2-yl)carbamate 
• 63062-22-6 3-(N-Methyl-N-phenylamino)-2-hydroxypropylamine 
• 82585-73-7 ethyl 6-amino-4-<<3-(N-methyl-N-phenylamino)-2-oxopropyl>amino>-5-nitro-2-pyridinecarbamate 

Downstream Products

• 83291-30-9 ethyl 5-amino-1,2,3,4-tetrahydro-3-[(N-methyl-N-phenylamino)methyl]pyrido[3,4-b]pyrazine-7-carbamate 
• 83269-13-0 ethyl 5-amino-3-[(N-methyl-N-phenylamino)methyl]pyrido[3,4-b]pyrazine-7-carbamate 
• 83269-14-1 5-amino-7-[(ethoxycarbonyl)amino]-N-methyl-N-phenylpyrido[3,4-b]pyrazine-3-carboxamide 

Relevant academic research and scientific papers

1,2-dihydropyrido[3,4-b]pyrazines

1,2-Dihydropyrido[3,4-b]pyrazines are provided which possess anticancer activity. The compounds have the structure: STR1 wherein Y is CH2 or N(CH3); R1 is a lower alkyl group; e.g., an alkyl group containing up to six carb

New Anticancer Agents: Synthesis of 1,2-Dihydropyridopyrizines (1-Deaza-7,8-dihydropteridines)

Reaction of α-aminoacetophenone oximes (2) with ethyl 6-amino-4-chloro-5-nitropyridine-2-carbamate (1) gave ethyl 6-amino-5-nitro-4-pyridine-2-carbamate oximes (3), which were hydrolyzed under acidic conditions to give the corresponding ketones (4).Related pyridines substituted with keto side chain were prepared from 1 and 1,3-diaminopropanone oximes and by oxidation of the side-chain hydroxy group of ethyl 6-amino-4-amino>-5-nitropyridine-7-carbamates (6).Catalytic hydrogenation of the nitro group of 4 over Raney nickel in a large volume of ethanol gave the 1-deaza-7,8-dihydropteridines (7).Several of the oximes 3 were successfully hydrogenated to give 7 directly.The resulting 1-deaza-7,8-dihydropteridines showed potent cytotoxicity against cultured L1210 cells and significant anticancer activity against lymphocytic leukemia P-388 in mice.THese biological activities are attributed to the accumulation of cells at mitosis.