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Usage

Uses

Used in Biochemical Research:
20-CARBOXY-LEUKOTRIENE B4 is used as a leukotriene B4 metabolite and substrate for β-oxidation pathways. It plays a crucial role in understanding the metabolic processes and biological activities of leukotrienes, which are important mediators in various physiological and pathological conditions, such as inflammation and immune responses.
Used in Pharmaceutical Development:
20-CARBOXY-LEUKOTRIENE B4 can be utilized in the development of drugs targeting leukotriene pathways. By studying its structure and activity, researchers can design and synthesize new compounds that modulate leukotriene production or action, potentially leading to novel therapeutic agents for treating inflammatory and immune disorders.
Used in Diagnostic Applications:
20-CARBOXY-LEUKOTRIENE B4 can be employed as a biomarker in diagnostic assays to assess the activity of leukotriene pathways in various diseases. Measuring the levels of 20-carboxy LTB4 in biological samples may help in diagnosing and monitoring the progression of conditions associated with altered leukotriene metabolism.
Used in Nutritional and Health Products:
20-CARBOXY-LEUKOTRIENE B4 may also find applications in the development of nutritional supplements and health products aimed at supporting a healthy immune system and reducing inflammation. By modulating leukotriene production or action, these products could potentially contribute to overall health and well-being.

InChI:InChI=1/C20H30O6/c21-17(11-6-2-1-3-9-15-19(23)24)12-7-4-5-8-13-18(22)14-10-16-20(25)26/h2,4-8,12-13,17-18,21-22H,1,3,9-11,14-16H2,(H,23,24)(H,25,26)/b5-4+,6-2-,12-7+,13-8-/t17-,18-/m1/s1

Upstream product

• 85615-54-9 (6Z,8E,10E,14Z)-(5S,12R)-5-Benzoyloxy-12-hydroxy-icosa-6,8,10,14-tetraenedioic acid 1-ethyl ester 20-methyl ester 
• 92640-98-7 trimethyl orthohept-6-ynoate 
• 106027-31-0 (8E,10E)-(5S,12R)-5,12-Bis-(tert-butyl-diphenyl-silanyloxy)-icosa-8,10-diene-6,14-diynedioic acid dimethyl ester 
• 106027-26-3 (R)-9-(tert-Butyl-diphenyl-silanyloxy)-10-(tetrahydro-pyran-2-yloxy)-dec-6-ynoic acid methyl ester 
• 106027-27-4 (R)-9-(tert-Butyl-diphenyl-silanyloxy)-10-hydroxy-dec-6-ynoic acid methyl ester 
• 106027-29-6 (R)-9-(tert-Butyl-diphenyl-silanyloxy)-10-oxo-dec-6-ynoic acid methyl ester 
• 106027-25-2 (R)-9-Hydroxy-10-(tetrahydro-pyran-2-yloxy)-dec-6-ynoic acid methyl ester 
• 928-90-5 5-hexyl-1-ol 
• 85593-66-4 (6Z,8E,10E,14Z)-(5S,12R)-5-Benzoyloxy-12-(tert-butyl-diphenyl-silanyloxy)-icosa-6,8,10,14-tetraenedioic acid 1-ethyl ester 20-methyl ester 
• 85593-65-3 [(2E,4E,8Z)-(R)-6-(tert-Butyl-diphenyl-silanyloxy)-13-methoxycarbonyl-trideca-2,4,8-trienyl]-triphenyl-phosphonium; bromide 
• 89682-31-5 (Z)-(R)-9-(tert-Butyl-diphenyl-silanyloxy)-9-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-non-6-enoic acid methyl ester 
• 85593-61-9 (Z)-(R)-9-(tert-Butyl-diphenyl-silanyloxy)-9-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-non-6-enoic acid 
• 85593-63-1 (6Z,10E,12E)-(R)-9-(tert-Butyl-diphenyl-silanyloxy)-14-oxo-tetradeca-6,10,12-trienoic acid methyl ester 
• 85593-64-2 (6Z,10E,12E)-(R)-9-(tert-Butyl-diphenyl-silanyloxy)-14-hydroxy-tetradeca-6,10,12-trienoic acid methyl ester 

Downstream Products

• 106046-38-2 (6Z,8E,10E,14Z)-(5S,12R)-5,12-Dihydroxy-icosa-6,8,10,14-tetraenedioic acid dimethyl ester 

Relevant academic research and scientific papers

TOTAL SYNTHESIS OF 20-HYDROXY- AND 20-CARBOXY-LEUKOTRIENES B4

The total synthesis of 20-hydroxy- and 20-carboxy-leukotrienes B4 (1 and 2) from key intermediates 13, 14 and 15 is described.

STEREOSPECIFIC SYNTHESIS OF TWO METABOLITES OF LTB4

The stereospecific synthesis of the recently identified metabolites of LTB4 1: 5(S),12(R),20-trihydroxy-6-cis,8,10-trans,14-cis-eicosatetraenoic acid 2 and 5(S),12(R),dihydroxy-6-cis,8,10-trans,14-cis-eicosatetraen-1,20-dioic acid 3, via the synthon 4 has been accomplished; identity of synthetic and natural products has been confirmed.