80434-82-8 Usage
Uses
Used in Biochemical Research:
20-CARBOXY-LEUKOTRIENE B4 is used as a leukotriene B4 metabolite and substrate for β-oxidation pathways. It plays a crucial role in understanding the metabolic processes and biological activities of leukotrienes, which are important mediators in various physiological and pathological conditions, such as inflammation and immune responses.
Used in Pharmaceutical Development:
20-CARBOXY-LEUKOTRIENE B4 can be utilized in the development of drugs targeting leukotriene pathways. By studying its structure and activity, researchers can design and synthesize new compounds that modulate leukotriene production or action, potentially leading to novel therapeutic agents for treating inflammatory and immune disorders.
Used in Diagnostic Applications:
20-CARBOXY-LEUKOTRIENE B4 can be employed as a biomarker in diagnostic assays to assess the activity of leukotriene pathways in various diseases. Measuring the levels of 20-carboxy LTB4 in biological samples may help in diagnosing and monitoring the progression of conditions associated with altered leukotriene metabolism.
Used in Nutritional and Health Products:
20-CARBOXY-LEUKOTRIENE B4 may also find applications in the development of nutritional supplements and health products aimed at supporting a healthy immune system and reducing inflammation. By modulating leukotriene production or action, these products could potentially contribute to overall health and well-being.
Check Digit Verification of cas no
The CAS Registry Mumber 80434-82-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,4,3 and 4 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 80434-82:
(7*8)+(6*0)+(5*4)+(4*3)+(3*4)+(2*8)+(1*2)=118
118 % 10 = 8
So 80434-82-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H30O6/c21-17(11-6-2-1-3-9-15-19(23)24)12-7-4-5-8-13-18(22)14-10-16-20(25)26/h2,4-8,12-13,17-18,21-22H,1,3,9-11,14-16H2,(H,23,24)(H,25,26)/b5-4+,6-2-,12-7+,13-8-/t17-,18-/m1/s1
80434-82-8Relevant academic research and scientific papers
TOTAL SYNTHESIS OF 20-HYDROXY- AND 20-CARBOXY-LEUKOTRIENES B4
Nicolaou, K. C.,Chung, Y. S.,Hernandez, P. E.,Taffer, I. M.,Zipkin, R. E.
, p. 1881 - 1882 (2007/10/02)
The total synthesis of 20-hydroxy- and 20-carboxy-leukotrienes B4 (1 and 2) from key intermediates 13, 14 and 15 is described.
STEREOSPECIFIC SYNTHESIS OF TWO METABOLITES OF LTB4
Zamboni, Robert,Rokach, Joshua
, p. 4751 - 4754 (2007/10/02)
The stereospecific synthesis of the recently identified metabolites of LTB4 1: 5(S),12(R),20-trihydroxy-6-cis,8,10-trans,14-cis-eicosatetraenoic acid 2 and 5(S),12(R),dihydroxy-6-cis,8,10-trans,14-cis-eicosatetraen-1,20-dioic acid 3, via the synthon 4 has been accomplished; identity of synthetic and natural products has been confirmed.
