80443-61-4Relevant academic research and scientific papers
Synthesis of Vicinal Quaternary All-Carbon Centers via Acid-catalyzed Cycloisomerization of Neopentylic Epoxides
Schmid, Matthias,Sokol, Kevin R.,Wein, Lukas A.,Torres Venegas, Sofia,Meisenbichler, Christina,Wurst, Klaus,Podewitz, Maren,Magauer, Thomas
supporting information, p. 6526 - 6531 (2020/09/02)
We report our studies on the development of a catalytic cycloisomerization of 2,2-disubstituted neopentylic epoxides to produce highly substituted tetralins and chromanes. Termination of the sequence occurs via Friedel-Crafts-type alkylation of the remote (hetero)arene linker. The transformation is efficiently promoted by sulfuric acid and proceeds best in 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) as the solvent. Variation of the substitution pattern provided detailed insights into the migration tendencies and revealed a competing disproportionation pathway of dihydronaphthalenes.
Process for the preparation of oxiranes
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, (2008/06/13)
A process for the preparation of oxiranes is disclosed in which a ketone of the formula STR1 wherein Y represents chlorine or phenyl, X represents oxygen or CH2 and Z represents hydrogen or halogen is reacted with trimethylsulphonium methyl sulphate formed by treating dimethyl sulphide with dimethyl sulphate. The process is carried out in the presence of potassium hydroxide or sodium hydroxide powder in an inert organic diluent at 0° to 60° C. The products are useful as intermediates for the formation of plant growth regulants and fungicides.
Antimicrobial azoles
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, (2008/06/13)
The invention relates to 1-hydroxylethyl-azole derivatives of formula (I) in composition form and includes the use of such compositions as antimicrobial agents.
Antiviral agents
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, (2008/06/13)
The invention relates to hydroxyethylazolyl derivatives, defined herein by formula (I) and particularly to the use of said derivatives for the treatment of viral infections.
Synergistic compositions for inhibiting plant growth
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, (2008/06/13)
A plant growth-inhibiting composition comprising STR1 wherein the various radicals are as defined.
