80445-66-5

Basic information

• Product Name: LEUKOTRIENE B5
• Synonyms: [5S,12R]-DIHYDROXY-[6Z,8E,10E,14Z,17Z]-EICOSAPENTAENOIC ACID;LTB5;LEUKOTRIENE B5;(5S,6Z,8E,10E,12R,14Z,17Z)-5,12-dihydroxyicosa-6,8,10,14,17-pentaenoic acid;5,12-Dihydroxy-6,8,10,14,17-icosapentaenoic acid
• CAS NO: 80445-66-5
• Molecular Formula: C20H30O4
• Molecular Weight: 334.45
• Mol File: 80445-66-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 538.7 °C at 760 mmHg
• Flash Point: 293.7 °C
• Appearance: /
• Density: 1.054 g/cm³
• Vapor Pressure: 7.47E-14mmHg at 25°C
• Refractive Index: 1.54
• Storage Temp.: −70°C
• CAS DataBase Reference: LEUKOTRIENE B5(CAS DataBase Reference)
• NIST Chemistry Reference: LEUKOTRIENE B5(80445-66-5)
• EPA Substance Registry System: LEUKOTRIENE B5(80445-66-5)

Safety Data

• Hazard Codes: F,Xi
• Statements: 11-36/37/38
• Safety Statements: 16-26-36
• RIDADR: UN 1170 3/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 80445-66-5(Hazardous Substances Data)

Usage

Uses

Leukotriene B5 is a derivative of Arachidonic Acid (A765000), which is an essential fatty acid. It is an inflammatory mediator produced by human neutrophils that is less potent but similar to Leukotriene B4 (L473510).

InChI:InChI=1/C20H30O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h3-4,6-11,14-15,18-19,21-22H,2,5,12-13,16-17H2,1H3,(H,23,24)/b4-3+,8-7+,9-6+,14-10+,15-11+

Upstream product

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• 2873-29-2 D-glucal triacetate 
• 89461-54-1 [(2R,3R)-((2Z,5Z)-3-Octa-2,5-dienyl)-oxiranyl]-methanol 
• 89408-86-6 (+)-(6S)-6-(hydroxymethyl)-3,4,5,6-tetrahydro-2H-pyran-2-one 
• 89408-88-8 (E)-Undec-2-ene-5,8-diyn-1-ol 
• 89408-91-3 (2R,3R)-2-[(Z)-4-(1-Methoxy-1-methyl-ethoxy)-but-1-enyl]-3-((2Z,5Z)-octa-2,5-dienyl)-oxirane 
• 89408-93-5 (Z)-4-[(2R,3R)-((2Z,5Z)-3-Octa-2,5-dienyl)-oxiranyl]-but-3-en-1-ol 
• 89408-92-4 (2R,3R)-2-((Z)-4-Iodo-but-1-enyl)-3-((2Z,5Z)-octa-2,5-dienyl)-oxirane 
• 89408-84-4 (2S)-acetic acid 6-oxo-5,6-dihydro-2H-pyran-2-ylmethyl ester 

Relevant articles and documents

TOTAL SYNTHESIS OF LEUKOTRIENE B5

A practical, stereocontrolled synthesis of leukotriene B5 is described which makes this substance readily available for the first time.