80446-61-3Relevant academic research and scientific papers
Rational electronic tuning of CBS catalyst for highly enantioselective borane reduction of trifluoroacetophenone
Korenaga, Toshinobu,Nomura, Kenji,Onoue, Kazutaka,Sakai, Takashi
supporting information; experimental part, p. 8624 - 8626 (2011/01/03)
α,α,α-Trifluoroacetophenone (2), which is susceptible to noncatalytic reduction by BH3, could be reduced to chiral alcohol up to 90% ee by using electronically tuned-CBS catalyst (1) with BH3. The enantioselectivities highly correlated with the differential orbital energies between 1-BH3 adduct and 2, which were calculated by DFT method.
Platinum-catalyzed enantioselective hydrogenation of aryl-substituted trifluoroacetophenones
Von Arx, Matthias,Mallat, Tamas,Baiker, Alfons
, p. 3089 - 3094 (2007/10/03)
The hydrogenation of 2,2,2-trifluoroacetophenones with different aryl-substituents (CF3, N(Me)2 and Me) has been studied over Pt/Al2O3 modified by cinchonidine, its hydrochloride or O-methyl cinchonidine. Electr
Reduction by a Model of NAD(P)H. 34. Substituent Effect on Asymmetric Reduction of Trifluoroacetophenones
Ohno, Atsuyoshi,Nakai, Jun-ichi,Nakamura, Kaoru,Goto, Takehiko,Oka, Shinzaburo
, p. 3486 - 3488 (2007/10/02)
Substituted and unsubstituted α,α,α-trifluoroacetophenones were reduced by a chiral NAD(P)H-model (R,R-Me2PNPH).Both electron-releasing and -withdrawing substituents give better optical yields than unsubstituted compound.The result has been interpreted in
