80446-62-4Relevant academic research and scientific papers
Reduction by a Model of NAD(P)H. 34. Substituent Effect on Asymmetric Reduction of Trifluoroacetophenones
Ohno, Atsuyoshi,Nakai, Jun-ichi,Nakamura, Kaoru,Goto, Takehiko,Oka, Shinzaburo
, p. 3486 - 3488 (1981)
Substituted and unsubstituted α,α,α-trifluoroacetophenones were reduced by a chiral NAD(P)H-model (R,R-Me2PNPH).Both electron-releasing and -withdrawing substituents give better optical yields than unsubstituted compound.The result has been interpreted in
Rational electronic tuning of CBS catalyst for highly enantioselective borane reduction of trifluoroacetophenone
Korenaga, Toshinobu,Nomura, Kenji,Onoue, Kazutaka,Sakai, Takashi
supporting information; experimental part, p. 8624 - 8626 (2011/01/03)
α,α,α-Trifluoroacetophenone (2), which is susceptible to noncatalytic reduction by BH3, could be reduced to chiral alcohol up to 90% ee by using electronically tuned-CBS catalyst (1) with BH3. The enantioselectivities highly correlated with the differential orbital energies between 1-BH3 adduct and 2, which were calculated by DFT method.
Platinum-catalyzed enantioselective hydrogenation of aryl-substituted trifluoroacetophenones
Von Arx, Matthias,Mallat, Tamas,Baiker, Alfons
, p. 3089 - 3094 (2007/10/03)
The hydrogenation of 2,2,2-trifluoroacetophenones with different aryl-substituents (CF3, N(Me)2 and Me) has been studied over Pt/Al2O3 modified by cinchonidine, its hydrochloride or O-methyl cinchonidine. Electr
