Unii-mqg94m5eeo, also known as Tesamorelin acetate, is an analog of growth hormone-releasing hormone (GHRH) that was approved in the United States in 2010 for the treatment of lipodystrophy in HIV patients. Tesamorelin is an analog of GHRH, which stimulates the synthesis and release of growth hormone (GH) in the pituitary gland. The secretion of GH is regulated by somatostatin and the negative feedback regulator, IGF-1. Tesamorelin is an amidated form of GHRH with a trans-3-hexenoyl group, which enhances its stability compared to native GHRH in animal models.
804475-66-9
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Basic information
- Product Name: Unii-mqg94m5eeo
- Synonyms: Tesamorelin;Th 9507;Th-9507;Unii-mqg94m5eeo
- CAS NO:804475-66-9
- Molecular Formula: C221H366N72O67S
- Molecular Weight: 5135.77794
- EINECS: N/A
- Product Categories: N/A
- Mol File: 804475-66-9.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: Unii-mqg94m5eeo(CAS DataBase Reference)
- NIST Chemistry Reference: Unii-mqg94m5eeo(804475-66-9)
- EPA Substance Registry System: Unii-mqg94m5eeo(804475-66-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 804475-66-9(Hazardous Substances Data)
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804475-66-9 Usage
Uses
Used in HIV Lipodystrophy Treatment:Unii-mqg94m5eeo is used as a therapeutic agent for the treatment of lipodystrophy in HIV patients. It helps to increase GH levels, which can improve the distribution of body fat and reduce the harmful effects of abnormal fat accumulation. The use of Tesamorelin as a GHRH analog provides an attractive mechanism for increasing GH levels without the side effects associated with direct GH administration, such as fluid retention and joint swelling.
Used in Pharmaceutical Industry:
Unii-mqg94m5eeo is used in the pharmaceutical industry as a stable and effective analog of GHRH. Its enhanced stability compared to native GHRH makes it a valuable compound for the development of new drugs and therapies targeting growth hormone-related conditions. The amidation of the N-terminal amino acid in Tesamorelin protects it from cleavage by DPP-4, further enhancing its potential applications in the pharmaceutical industry.
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Theratechnologies (Canada)Check Digit Verification of cas no
The CAS Registry Mumber 804475-66-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,0,4,4,7 and 5 respectively; the second part has 2 digits, 6 and 6 respectively.Calculate Digit Verification of CAS Registry Number 804475-66:
(8*8)+(7*0)+(6*4)+(5*4)+(4*7)+(3*5)+(2*6)+(1*6)=169
169 % 10 = 9
So 804475-66-9 is a valid CAS Registry Number.
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804475-66-9Downstream Products
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Unii-mqg94m5eeo
