804555-44-0Relevant articles and documents
Discovery of a potent and short-acting oral calcilytic with a pulsatile secretion of parathyroid hormone
Shinagawa, Yuko,Inoue, Teruhiko,Katsushima, Takeo,Kiguchi, Toshihiro,Ikenogami, Taku,Ogawa, Naoki,Fukuda, Kenji,Hirata, Kazuyuki,Harada, Kazuhito,Takagi, Masaki,Nakagawa, Takashi,Kimura, Shuichi,Matsuo, Yushi,Maekawa, Mariko,Hayashi, Mikio,Soejima, Yuki,Takahashi, Mitsuru,Shindo, Masanori,Hashimoto, Hiromasa
, p. 238 - 242 (2011/04/26)
Short-acting oral calcilytics, calcium-sensing receptor (CaSR) antagonists, have been considered as alternatives for parathyroid hormone (PTH), an injectable bone anabolic drug used in the treatment of osteoporosis. Previously, we identified aminopropandi
CaSR ANTAGONIST
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Page/Page column 45-46, (2008/06/13)
The present invention provides a compound having a calcium-sensitive receptor antagonistic action, a pharmaceutical composition containing the compound, particularly a calcium receptor antagonist and a therapeutic drug for osteoporosis. A compound represented by the following formula (1), a pharmaceutically acceptable salt thereof or an optically active form thereof: wherein each symbol is as defined in the description.