80459-46-7

Upstream product

• 100-83-4 meta-hydroxybenzaldehyde 
• 98-59-9 p-toluenesulfonyl chloride 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 93710-49-7 3-tosyloxyphenethylamine 
• 93710-47-5 3-tosyloxybenzylchloride 
• 93710-48-6 3-tosyloxybenzylcyanide 
• 93710-60-2 N-(3-hydroxyphenethyl)-2-(2-bromo-3-isopropoxy-4-methoxyphenyl)acetamide 
• 93710-59-9 N-(3-tosyloxyphenethyl)-2-(2-bromo-3-isopropoxy-4-methoxyphenyl)acetamide 
• 1181294-97-2 3-formyl-2’-nitrobiphenyl 
• 1425968-54-2 2,5,9-trioxa-1⁴-benzoyl-1,4(1,3),7(1,4)-tribenzena cyclononaphane 
• 1425968-57-5 3,7,10-trioxa-1³-phenyl-1(2,6)-benzofurana-2,8(1,3),5(1,4)-tribenzenacyclodecaphane 
• 1425968-58-6 2-oxo-5,8-dioxa-1⁶-benzoyl-1,6(1,3),3(1,4)-tribenzena cyclooctaphane 
• 1425968-59-7 5,8-dioxa-1⁶-benzoyl-2-hydroxy-1,6(1,3),3(1,4)-tribenzenacyclooctaphane 
• 1425968-55-3 3-(tosyloxy)benzyl alcohol 
• 1425968-56-4 2,4-bis[3'-(hydroxyl)benzyloxy]benzophenone 
• 1425968-62-2 2-hydroxy-4-[3′-(tosyloxy)benzyloxy]benzophenone 
• 1425968-63-3 2-hydroxy-4-[3'-(hydroxy)benzyloxy]benzophenone 

Relevant academic research and scientific papers

Thiazole amide compound and preparation method, pharmaceutical composition and application thereof

The invention discloses a thiazole amide compound and a preparation method thereof, a pharmaceutical composition and application thereof. The thiazole amide compound as shown in a formula I and a pharmaceutically acceptable salt thereof are provided, and

Synthesis of Tetranuclear Palladium(II) Complexes and Their Catalytic Activity for Cross-Coupling Reactions

We have developed a short and simple synthesis of tetranuclear palladium(II) complexes that have been structurally confirmed by X-ray analysis. These complexes were formed in about 30 % overall yield by spontaneous metalation of dimethylaminoarene derivatives and exhibit a high stability. We have studied the utility of the tetranuclear palladium(II) complexes as precatalysts for Mizoroki–Heck and Suzuki–Miyaura cross-coupling reactions. Our novel complexes show excellent catalytic activities with high turnover numbers (TON) and high turnover frequencies (TOF) (e.g., for the Suzuki–Miyaura reaction: TON up to 538000 and TOF up to 23400 h?1 at room temperature).

Cyclophane size drives the photochemical behaviour of benzophenone

A new series of all-heterahomocalixarene-type structures was prepared. The new hetera[2n]metacyclophanes obtained contain a benzophenone moiety as photoactive component. Although both forms possess identical building blocks and differ only in r

Decarboxylative cross-coupling of aryl tosylates with aromatic carboxylate salts

(Figure Presented) A bimetallic copper/palladium catalyst system is disclosed that enables the use of tosylates as carbon electrophiles in decarboxylative coupling reactions. A variety of aromatic carboxylate salts, regardless of their substitution pattern, have been coupled with these inexpensive and readily available electrophiles to give the corresponding biaryl compounds in good yields (see scheme).

Preparation of polyfunctional arylmagnesium, arylzinc, and benzylic zinc reagents by using magnesium in the presence of LiCl

The presence of LiCl considerably facilitates the insertion of magnesium into various aromatic and heterocyclic bromides. Several functional groups, such as -OBoc, -OTs, -Cl, -F, -CF3, -OMe, -NMe2, and -N 2NR2, are well tolerated. The presence of a cyano group leads in some cases to competitive reduction of the organic halide to the corresponding ArH compound. The presence of sensitive groups such as methyl or ethyl ester is tolerated upon in situ trapping of the intermediate magnesium reagent with ZnCl2. This method can also be applied to the preparation of functionalized benzylic zinc reagents from benzylic chlorides. In the case of di- or tribromoaryl derivatives, directing groups such as -OPiv, -OTs, -N2NR2, or -OAc orient the zinc insertion (Zn/LiCl) to the ortho-position, while the reaction with Mg/LiCl or Mg/LiCl/ZnCl 2 leads to regioselective insertion into the para-carbon-bromine bond. Large-scale experiments (20-100 mmol) for all of the metalation procedures are described.

Convenient preparation of polyfunctional aryl magnesium reagents by a direct magnesium insertion in the presence of LiCl

(Chemical Equation Presented) In the footsteps of Victor Grignard: The simple LiCl-mediated insertion of magnesium into aryl chlorides and bromides at moderate temperatures leads to functionalized organomagnesium reagents (see scheme). An unprecedented range of functional groups may be present in the substrates (e.g. CN, CO2R, OTs, OBoc; Ts=p-toluenesulfonyl, Boc=tert-butylcarbonyloxy).

NEODIHYDROTHEBAINE AND BRACTAZONINE, TWO DIBENZAZONINE ALKALOIDS OF PAPAVER BRACTEATUM

Two new dibenzazonine alkaloids, neodihydrothebaine and bractazonine were isolated from Papaver bracteatum.Their possible biosynthesis from thebaine is discussed.The structures of both new alkaloids are proven by synthesis.An isomeric dibenzazonine compound was also prepared. - Keywords: Papaver bracteatum; Papaveraceae; alkaloids; dibenzazonines; neodihydrothebaine; bractazonine; biosynthetic pathway; synthesis; 5,6,8,9-tetrahydro-2-methoxy-7-methyl-dibenzazonin-1,12-diol; 5,6,8,9-tetrahydro-2,10-dimethoxy-7-methyl-dibenzazonin-1-ol; 5,6,8,9-tetrahydro-2,11-dimethoxy-7-methyl-dibenz-azonin-1-ol; 5,6,8,9-tetrahydro-2,12-dimethoxy-7-methyl-dibenzazonin-1-ol.