80474-27-7

Basic information

• Product Name: 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-, S-(bromomethyl)ester, (6α,11β,16α,17α)-
• Synonyms: 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-, S-(bromomethyl)ester, (6α,11β,16α,17α)-;Androsta-1,4-diene-17- carbothioic acid, 6,9-difluoro-11 -hydroxy-16-Methyl-3-oxo-17-(1-oxopropoxy)-,S-(broMoMethyl)ester, (6α,11β,16α,17α)-
• CAS NO: 80474-27-7
• Molecular Formula: C25H31BrF2O5S
• Molecular Weight: 561.4764464
• Mol File: 80474-27-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-, S-(bromomethyl)ester, (6α,11β,16α,17α)-(CAS DataBase Reference)
• NIST Chemistry Reference: 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-, S-(bromomethyl)ester, (6α,11β,16α,17α)-(80474-27-7)
• EPA Substance Registry System: 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)-, S-(bromomethyl)ester, (6α,11β,16α,17α)-(80474-27-7)

Safety Data

• Hazardous Substances Data: 80474-27-7(Hazardous Substances Data)

Relevant articles and documents

ANDROSTANE CARBOTHIOATES

Compounds of the formula wherein R1 represents a fluoro-, chloro- or bromo-methyl group or a 2'-fluoroethyl group, R2 represents a group COR6 where R6 is a C 1-3 alkyl group or OR2 and R3 together form a 16alpha,17alpha-isopropylidenedioxy group; R3 represents a hydrogen atom, a methyl group (which may be in either the alpha- or beta -configuration) or a methylene group; R4 represents a hydrogen, chlorine or fluorine atom; R5 represents a hydrogen or fluorine atom and symbol represents a single or double bond have good anti-inflammatory activity, particularly on topical applications. The compounds of formula I are prepared by esterification, halogenation, reduction, deprotection and reaction at a 9,11-double bond to form a 9alpha-halo-11 beta-hydroxy grouping. Pharmaceutical compositions containing the compounds of formula I and methods for the use of the compounds are described and claimed