80474-99-3

Basic information

• Product Name: TETRAETHYL(AMINOMETHYLENE)BISPHOSPHONATE OXALATE SALT
• Synonyms: TETRAETHYL(AMINOMETHYLENE)BISPHOSPHONATE;TETRAETHYL(AMINOMETHYLENE)BISPHOSPHONATE OXALATE SALT;Tetraethyl(aminomethylene)bisphosphonate, min. 90 %;Phosphonic acid, (aMinoMethylene)bis-, tetraethyl ester;Tetraethyl (aminomethanediyl)bis(phosphonate), Bis(diethoxyphosphoryl)methylamine;bis(Diethoxyphosphoryl)methanamine
• CAS NO: 80474-99-3
• Molecular Formula: C₉H₂₃NO₆P₂
• Molecular Weight: 303.23
• Mol File: 80474-99-3.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: TETRAETHYL(AMINOMETHYLENE)BISPHOSPHONATE OXALATE SALT(CAS DataBase Reference)
• NIST Chemistry Reference: TETRAETHYL(AMINOMETHYLENE)BISPHOSPHONATE OXALATE SALT(80474-99-3)
• EPA Substance Registry System: TETRAETHYL(AMINOMETHYLENE)BISPHOSPHONATE OXALATE SALT(80474-99-3)

Safety Data

• Hazardous Substances Data: 80474-99-3(Hazardous Substances Data)

Usage

General Description

TETRAETHYL(AMINOMETHYLENE)BISPHOSPHONATE OXALATE SALT is a chemical compound that is a salt form of bisphosphonate. It is commonly used in the treatment of osteoporosis and other bone diseases, as it helps to prevent bone breakdown and can also aid in bone formation. TETRAETHYL(AMINOMETHYLENE)BISPHOSPHONATE OXALATE SALT works by inhibiting the activity of osteoclasts, the cells responsible for bone resorption, and is also believed to have anti-inflammatory and anti-cancer properties. TETRAETHYL(AMINOMETHYLENE)BISPHOSPHONATE OXALATE SALT is typically administered orally or intravenously and is considered to be relatively safe and well-tolerated when used as directed by a healthcare professional.

Upstream product

• 77287-34-4 formamide 
• 122-52-1 triethyl phosphite 
• 80474-97-1 tetraethyl (N,N-dibenzyl)aminomethyl-bis(phosphonate) 

Downstream Products

• 29712-28-5 aminomethylenebis(phosphonic acid) 
• 303069-19-4 tetraethyl (E)-N-(2-thiophenemethyliden)aminomethyldiphosphonate 
• 303069-16-1 tetraethyl (E)-N-(2-allyloxybenzyliden)aminomethyldiphosphonate 
• 1042684-38-7 diethyl [(diethoxyphosphoryl)-(2-methylpropenylimino)methyl]phosphonate 
• 1042684-35-4 C₁₆H₃₁NO₆P₂ 
• 1042684-32-1 C₂₃H₃₁NO₆P₂ 
• 1042684-36-5 C₁₅H₃₁NO₆P₂ 
• 1132710-10-1 tetraethyl {[(3-chlorobenzylidene)amino]methylene}diphosphonate 
• 1025816-19-6 (E)?benzyl (1?(diethoxyphosphoryl)?2?phenylvinyl)carbamate 

Relevant articles and documents

Al(OH)3 facilitated synthesis of water-soluble, magnetic, radiolabelled and fluorescent hydroxyapatite nanoparticles

Magnetic and fluorescent hydroxyapatite nanoparticles were synthesised using Al(OH)3-stabilised MnFe2O4 or Fe3O4 nanoparticles as precursors. They were readily and efficiently radiolabelled with 18F. Bisphosphonate polyethylene glycol polymers were utilised to endow the nanoparticles with excellent colloidal stability in water and to incorporate cyclam for high affinity labelling with 64Cu.

1-Aminovinylphosphonate Esters as Substrates for the Diels-Alder Reaction: First Synthetic and Theoretical Study

The Diels-Alder reaction of 1-aminovinylphosphonate esters has been studied for the first time as a suitable procedure leading to quaternary carbocyclic α-aminophosphonates. The reaction is influenced by steric effects at the phosphonate functionality (bulky groups hinder the reaction) and electronic effects at the amino group (electron-withdrawing substituents increase the reaction rate). The exo/endo ratio is constant, and no influence of the solvent is observed. The experimental results have been rationalized by DFT methods.

COMPOUND FOR BONE SCANNING AND USE THEREOF

The disclosure provides a compound comprising bisphosphonate functional group and chelating agent. The bisphosphonate functional group part has high affinity for bone tissue, and the chelating agent part has high affinity for metal tracer such as radioisotope. The disclosed compound could be rapidly adsorbed onto the bone surface, and could steady emit ionizing radiation. Therefore, the disclosed compound is suitable for bone scanning technology to find abnormalities in bone.