80477-76-5

Basic information

• Product Name: 5-methyl-2-(pyridin-2-yl)-1-[2-(pyridin-2-yl)ethyl]-1H-benzimidazole
• Synonyms: 5-Methyl-2-(2-pyridinyl)-1-(2-(2-pyridinyl)ethyl)-1H-benzimidazole
• CAS NO: 80477-76-5
• Molecular Formula: C₂₀H₁₈N₄
• Molecular Weight: 314.3837
• Mol File: 80477-76-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 540°C at 760 mmHg
• Flash Point: 280.4°C
• Density: 1.18g/cm³
• Vapor Pressure: 9.98E-12mmHg at 25°C
• Refractive Index: 1.658
• CAS DataBase Reference: 5-methyl-2-(pyridin-2-yl)-1-[2-(pyridin-2-yl)ethyl]-1H-benzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-2-(pyridin-2-yl)-1-[2-(pyridin-2-yl)ethyl]-1H-benzimidazole(80477-76-5)
• EPA Substance Registry System: 5-methyl-2-(pyridin-2-yl)-1-[2-(pyridin-2-yl)ethyl]-1H-benzimidazole(80477-76-5)

Safety Data

• Hazardous Substances Data: 80477-76-5(Hazardous Substances Data)

Upstream product

• 100-69-6 2-vinylpyridine 
• 7471-12-7 5-methyl-2-(pyridin-2-yl)-1H-benzo[d]imidazole 

Relevant articles and documents

ACIDIC PROPERTIES OF BENZIMIDAZOLES AND SUBSTITUENT EFFECTS. V. PROTECTION OF BENZIMIDAZOLES BY N-ALKYL BOND FORMATION USING VINYLPYRIDINES

Vinylpyridines were utilized for protection of the benzimidazole N-H bond to give 1-(2-pyridylethyl)-benzimidazoles.The reaction was found to progress smoothly when glacial acetic acid was used as a catalyst.In the alkylation of 5- or 7-substituted-2-arylbenzimidazoles with vinylpyridines, the yield decreased with increasing electron-attracting effect of the substituent groups in the benzimidazole ring.On the other hand, the removal of pyridylethyl groups by the use of aluminum chloride as a catalyst was kinetically examined; a large excess of sodium hydroxide was used for decomposition of the intermediate adduct of aluminum chloride.The rate increased somewhat when electron-releasing substituent groups were present in the benzimidazole ring. 1--2-arylbenzimidazoles were resistant to removal of their (2-pyridyl)ethyl groups. 4-Vinylpyridine can be used more efficiently as a protecting agent.Keywords: 2-pyridylbenzimidazoles; protection with vinylpyridines for imidazole; 1-(2-pyridylethyl)-benzimidazoles; substituent effect on N-alkylation of benzimidazoles; rate of removal of pyridylethyl groups by aluminum chloride catalyst