80479-71-6Relevant academic research and scientific papers
BENZOQUINONE DERIVATIVES AS MODULATORS OF MITCHONDRIAL FUNCTION
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Page/Page column 37, (2012/03/10)
The present invention relates to benzoquinone derivatives which are efficient as modulators of mitochondrial function and as such are useful for the treatment of pathological conditions where mitochondrial function is impaired.
Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria
Duveau, Damien Y.,Arce, Pablo M.,Schoenfeld, Robert A.,Raghav, Nidhi,Cortopassi, Gino A.,Hecht, Sidney M.
experimental part, p. 6429 - 6441 (2010/10/03)
Analogues of mitoQ and idebenone were synthesized to define the structural elements that support oxygen consumption in the mitochondrial respiratory chain. Eight analogues were prepared and fully characterized, then evaluated for their ability to support oxygen consumption in the mitochondrial respiratory chain. While oxygen consumption was strongly inhibited by mitoQ analogues 2-4 in a chain length-dependent manner, modification of idebenone by replacement of the quinone methoxy groups by methyl groups (analogues 6-8) reduced, but did not eliminate, oxygen consumption. Idebenone analogues 6-8 also displayed significant cytoprotective properties toward cultured mammalian cells in which glutathione had been depleted by treatment with diethyl maleate.
