80504-52-5Relevant academic research and scientific papers
Design, modeling & synthesis of 1,2,3-triazole-linked nucleoside-amino acid conjugates as potential antibacterial agents
Malkowski, Sarah N.,Dishuck, Carolyn F.,Lamanilao, Gene G.,Embry, Carter P.,Grubb, Christopher S.,Cafiero, Mauricio,Peterson, Larryn W.
, (2017/11/07)
Copper-catalyzed azide-alkyne cycloadditions (CuAAC or click chemistry) are convenient methods to easily couple various pharmacophores or bioactive molecules. A new series of 1,2,3- Triazole-linked nucleoside-amino acid conjugates have been designed and synthesized in 57-76% yields using CuAAC. The azido group was introduced on the 50-position of uridine or the acyclic analogue using the tosyl-azide exchange method and alkylated serine or proparylglycine was the alkyne. Modeling studies of the conjugates in the active site of LpxC indicate they have promise as antibacterial agents.
