80504-89-8

Basic information

• Product Name: dibenzyl hydroxyimino<2-13C>malonate
• CAS NO: 80504-89-8
• Molecular Weight: 314.299
• Mol File: 80504-89-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: dibenzyl hydroxyimino<2-13C>malonate(CAS DataBase Reference)
• NIST Chemistry Reference: dibenzyl hydroxyimino<2-13C>malonate(80504-89-8)
• EPA Substance Registry System: dibenzyl hydroxyimino<2-13C>malonate(80504-89-8)

Safety Data

• Hazardous Substances Data: 80504-89-8(Hazardous Substances Data)

Upstream product

• 67024-20-8 dibenzyl <2-13C>malonate 

Downstream Products

• 67024-22-0 C₁₉⁽¹³⁾CH₂₁NO₇ 
• 67024-19-5 benzyl 3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-5-methyl<2-13C>pyrrole-2-carboxylate 

Relevant articles and documents

Biosynthesis of Porphyrins and Related Macrocycles. Part 16. Proof that the Single Intramolecular Rearrangement leading to Natural Porphyrins (Type-III) occurs at the Tetrapyrrole Level

The unrearranged aminomethylbilane (2) is synthesised by a rational route and is proved to be converted by the enzymes deaminase and cosynthetase, working co-operatively, into uro'gen-III (3).The single rearrangement step established earlier is thus proved to take place at the tetrapyrrole level.Synthesis of singly 13C-labelled bilane (2) followed by its enzymic conversion into uro'gen-III serves to register each of the pyrrole rings of the product relative to the initial bilane.Finally, methods for synthesis of the bilane are developed in two different doubly 13C-labelled forms to allow the following key points to be established largely by 13C n.m.r. spectroscopy: (a) as the bilane system is converted into uro'gen-III, intramolecular rearrangement of the terminal ring D occurs, and (b) the linear tetrapyrrole is converted intact into uro'gen-III.Syntheses of -, and -uroporphyrin octamethyl ester are described together with improved h.p.l.c. conditions for the separation of isomeric coproporphyrin tetramethyl esters.