805231-37-2

Upstream product

• 805231-36-1 (6R,7R)-7-Allyloxycarbonylamino-8-oxo-3-(1,2,2,2-tetrachloro-ethoxycarbonyloxymethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 805231-42-9 benzhydryl 7-(allyloxycarbonylamino)cephalosporinate 
• 129543-55-1 (6R,7R)-7-Allyloxycarbonylamino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 16901-30-7 7-(allyloxycarbonylamino)cephalosporanic acid 
• 1026002-23-2 (6R,7R)-7-Allyloxycarbonylamino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 957-68-6 7-Aminocephalosporanic acid 
• 27266-61-1 benzhydryl 7-aminocephalosporanate 
• 805231-43-0 (6R,7R)-7-Allyloxycarbonylamino-3-[4-((R)-3-ethyl-2,6-dioxo-piperidin-3-yl)-phenylcarbamoyloxymethyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 

Relevant academic research and scientific papers

Toward the development of a cephalosporin-based dual-release prodrug for use in ADEPT

In previous work we have shown that a cephalosporin structure bearing an S-aminosulfenimine at the 7-position behaved as a β-lactamase-dependent dual-release prodrug. Scission of the β-lactam ring of such a structure led to the rapid loss of the sulfur-at