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Usage

Uses

Used in Pharmaceutical Research and Organic Synthesis:
2,4-dioxoheptanoic acid ethyl ester is utilized as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its versatile reactivity and chemical properties make it a key component in developing new compounds with potential therapeutic and agricultural applications.
Used in the Development of New Materials:
2,4-dioxoheptanoic acid ethyl ester has been studied for its potential use in the development of new materials, indicating its broad applicability beyond traditional pharmaceutical and chemical synthesis.
Used in the Food Industry as a Flavoring Agent:
2,4-dioxoheptanoic acid ethyl ester is also considered for use as a flavoring agent in the food industry, capitalizing on its fruity odor to enhance the sensory experience of food products.

Upstream product

• 107-87-9 2-Pentanone 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 76424-47-0 5-propyl-1H-pyrazole-3-carboxylic acid 
• 92945-27-2 5-propyl-1H-pyrazole-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Pyrazole derivatives as partial agonists for the nicotinic acid receptor

Nicotinic acid as a hypolipidemic agent appears unique due to its potential to increase HDL cholesterol levels to a greater extent than other drugs. However, it has some side effects, among which severe skin flushing is the most frequent and often limits patients' compliance. In a search for novel agonists for the recently identified and cloned G protein-coupled nicotinic acid receptor, we synthesized a series of substituted pyrazole-3-carboxylic acids that proved to have substantial affinity for this receptor. The affinities were measured by inhibition of [3H] nicotinic acid binding to rat spleen membranes. Potencies and intrinsic activities relative to nicotinic acid were determined by their effects on [35S]GTPγS binding to rat adipocyte and spleen membranes. Interestingly, most compounds were partial agonists. In particular, 2-diazabicyclo-[3,3,O 4,8]octa-3,8-diene-3-carboxylic acid (4c) and 5-propylpyrazole-3-carboxylic acid (4f) proved active with Ki values of approximately 0.15 μM and EC50 values of approximately 6 μM, while their intrinsic activity was only ～50% when compared to nicotinic acid. Even slightly more active was 5-butylpyrazole-3-carboxylic acid (4g) with a Ki value of 0.072 μM, an EC50 value of 4.12 μM, and a relative intrinsic activity of 75%. Of the aralkyl derivatives, 4q (5-(3-chlorobenzyl)pyrazole-3-carboxylic acid) was the most active with a relatively low intrinsic activity of 39%. Partial agonism of the pyrazole derivatives was confirmed by inhibition of G protein activation in response to nicotinic acid by these compounds. The pyrazoles both inhibited the maximum effect elicited by 100 μM nicotinic acid and concentration dependently shifted nicotinic acid concentration-response curves to the right, pointing to a competive mechanism of action.