80547-76-8 Usage
Uses
Used in Organic Synthesis:
Ethanone, 1-(3,4-dimethoxy-5-methylphenyl)is utilized as a key intermediate in organic synthesis for the preparation of a variety of chemical compounds. Its unique structure allows for versatile reactions and modifications, facilitating the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, Ethanone, 1-(3,4-dimethoxy-5-methylphenyl)- is employed as a starting material for the development of new drugs. Its specific structural features and potential biological activities make it a promising candidate for the synthesis of pharmaceutical agents with novel mechanisms of action.
Used in Medicinal Chemistry:
Ethanone, 1-(3,4-dimethoxy-5-methylphenyl)is applied in medicinal chemistry for the design and synthesis of innovative therapeutic agents. The exploration of its properties and activities can lead to the discovery of new drugs with improved efficacy and selectivity for various medical conditions.
Used in Biological Activity Studies:
Ethanone, 1-(3,4-dimethoxy-5-methylphenyl)-'s 3,4-dimethoxy-5-methylphenyl group may endow it with specific biological activities that are of interest for research. It is used in biological assays and screenings to evaluate its potential as a lead compound for drug discovery, particularly in identifying new pharmacological targets and therapeutic approaches.
Check Digit Verification of cas no
The CAS Registry Mumber 80547-76-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,5,4 and 7 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 80547-76:
(7*8)+(6*0)+(5*5)+(4*4)+(3*7)+(2*7)+(1*6)=138
138 % 10 = 8
So 80547-76-8 is a valid CAS Registry Number.
80547-76-8Relevant academic research and scientific papers
Catechol O-methyltransferase. 12. Affinity Labeling the Active Site with the Oxidation Products of 5,6-Dihydroxyindole
Borchardt, Ronald T.,Bhatia, Pramila
, p. 263 - 271 (2007/10/02)
5,6-Dihydroxyindole (5,6-DHI) and a series of 4- and/or 7-methylated analogues of 5,6-DHI have been synthesized and evaluated for their ability to inactivate purified liver rat catechol O-methyltransferase (COMT).The inactivation of COMT by these agents could be prevented by excluding oxygen from the incubation mixtures, indicating the necessity for their oxidation to the corresponding aminochromes.Substrate protection studies and kinetic studies suggested that the loss of enzyme activity resulted from the modification of a crucial amino acid residue at the active site of COMT through reaction with the quinoid oxidation products.The COMT inhibitory activity of the 4- and/or 7-methylazed analogues of 5,6-DHI argue against a mechanism involving a 1,4 Michael addition reaction at positions 4 or 7 on the aminochrome.Cnsidering the number of potential eletrophilic centers on the basic aminochrome structure, the site of the reaction might change depending on the aromatic substitution pattern.The preferred pathway of reaction may be determined in part by the juxtaposition of the protein nucleophile to the possible sites of attack on the electrophilic ligand but also in part on the reactivity of the electrophilic site which might change with substitution on the aromatic ring.
