80554-47-8Relevant academic research and scientific papers
Discovery of oxime-bearing naphthalene derivatives as a novel structural type of Nrf2 activators
Chang, Ken-Ming,Liang, Fong-Pin,Chen, I-Li,Yang, Shyh-Chyun,Juang, Shin-Hun,Wang, Tai-Chi,Chen, Yeh-Long,Tzeng, Cherng-Chyi
, p. 3852 - 3859 (2015/08/03)
Abstract Recent studies have demonstrated that oxidative stress insult is one of major causes of tumor formation. Therefore, identify the effective anti-oxidative agents as a preventive approach to stop cancer progression has widely explored. Although, ma
Regioselective preparation of benzo[b]furans from Phenols and α-Bromoketones
Arias, Leire,Vara, Yosu,Cossio, Fernando P.
experimental part, p. 266 - 275 (2012/02/05)
In this paper, a fully regiocontrolled synthesis of either 2- and 3-substituted benzo[b]furans is described. Direct reaction between phenols and α-bromoacetophenones in the presence of neutral alumina yields 2-substituted benzo[b]furans with complete regiocontrol. When a basic salt such as potassium carbonate is used, the corresponding 2-oxoether is obtained. Cyclization of these latter compounds promoted by neutral alumina yields the corresponding 3-substituted benzo[b]furans. Using the former method, Moracin M and other analogues can be obtained from commercial sources in two preparative steps. DFT calculations provide reasonable reaction paths to understand the formation of 2-substituted benzo[b]furans.
BCl3-promoted synthesis of benzofurans
Kim, Ikyon,Lee, Sei-Hee,Lee, Sunkyung
body text, p. 6579 - 6584 (2009/04/06)
Lewis acidic nature of boron trichloride (BCl3) to coordinate to the carbonyl functionality was exploited for the synthesis of benzofurans via dehydrative cyclization. This mild and efficient procedure allowed for facile access to a number of h
Synthesis and cytotoxic evaluation of a series of γ-substituted γ-aryloxymethyl-α-methylene-γ-butyrolactones against cancer cells
Tzeng,Lee,Wang,Han,Chen
, p. 715 - 719 (2007/10/03)
Purpose. The main objective of this investigation was to explore the cytotoxic structure-activity relationships of γ-substituted γ-aryloxy-methyl-α-methylene-γ-butyrolactones against cancer cells. Methods. The target compounds were synthesized in two step
Three-step synthesis of an array of substituted benzofurans using polymer-supported reagents
Habermann, Joerg,Ley, Steven V.,Smits, Rene
, p. 2421 - 2423 (2007/10/03)
An efficient combinatorial route to substituted 3-phenyl-benzofurans, is achieved by the bromination of acetophenones to α-bromoacetophenones by polymer-supported pyridinium bromide perbromide (PSPBP). The subsequent clean substitution of the obtained bromides by phenols using 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD-P) and cyclodehydration of the resulting α-phenoxyacetophenones using Amberlyst 15, affords pure products without the need for any chromatographic purification step.
