80565-32-8Relevant academic research and scientific papers
Dioxolane derivatives
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, (2008/06/13)
The invention is concerned with novel dioxolane derivatives of the formula: STR1 in which Ra is hydrogen or (1-4C)alkyl and Rb is (1-4C)alkyl or phenyl optionally bearing a halogeno substituent; their production; and their use for the manufacture of certain known anti-arthritic acids of the formula: STR2 and, in particular, those acids in which Ra =Rb =methyl or Ra =ethyl and Rb =phenyl, by a novel reduction process. The preferred reduction procedures involve the use of an alkali metal borohydride or cyanoborohydride in the presence of a noble metal catalyst, or the use of an α-branched alkyl or cycloalkyl Grignard agent. The use of the derivatives of formula I avoids the need for potentially toxic reagents and reactive intermediates in the previously known processes for the production of the acids of formula V.
