80565-57-7Relevant academic research and scientific papers
2-substituted-3-indolamines and use thereof as anti-diabetics
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, (2008/06/13)
This disclosure relates to substituted indolamines, which exhibit anti-diabetic activity, having the formula: STR1 where m is an integer from 1 to 4, x represents hydrogen or --OH R represents Ar or STR2 and Ar represents STR3 R1 represents hydrogen, fluoro, chloro, lower alkyl or lower alkoxy, R2 and R3 each, independently, represent lower alkyl, or R2 and R3 together with N represent STR4 wherein n is 1, 2 or 3, R4 represents hydrogen or lower alkyl, and R5 represents hydrogen or lower alkyl, unsubstituted phenyl or phenyl substituted with fluoro, chloro, lower alkyl or lower alkoxy, or or pharmaceutically acceptable acid addition salts thereof.
Isoxazolyl indolamines having anti-diabetic activity
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, (2008/06/13)
This disclosure describes novel compounds of the formula STR1 where m is 2, 3 or 4 X is hydrogen or hydroxy R1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms or lower alkoxy having 1 to 4 carbon atoms, and R2 and R3 each independently represent lower alkyl as defined above, or R2 and R3 together with N represent STR2 wherein n is 1, 2 or 3, and R4 represents hydrogen or lower alkyl as defined above, and R5 represents hydrogen, lower alkyl, phenyl or phenyl substituted with fluoro, chloro, lower alkyl having 1 to 4 carbon atoms, or lower alkoxy having 1 to 4 carbon atoms, with the proviso that when X is hydroxy, m is 3 or 4, or a pharmaceutically acceptable acid addition salt thereof, which are useful in the treatment of diabetes by inhibiting or impeding post-prandial hyperglycemia.
Isoxazolyl indolamines
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, (2008/06/13)
This disclosure describes compounds of the formula STR1 wherein R1 represents hydrogen, fluoro, chloro, lower alkyl having 1 to 4 carbon atoms, or lower alkoxy having 1 to 4 carbon atoms, and R2 represents lower alkyl or STR2 where R5 represents hydrogen, fluoro, chloro, lower alkyl or lower alkoxy, and R3 and R4 each independently represent lower alkyl as defined above, and R3 and R4 together with N represent STR3 or pharmaceutically acceptable acid addition salts thereof, which are useful as anti-diabetic agents.
