80589-68-0Relevant academic research and scientific papers
Anti-Inflammatory Agents: Part V - Synthesis of Some New 4-(4,5-Disubstituted-oxazol-2-yl)phenylacetic Acids and their Methyl Esters
Shridhar, D. R.,Ram, Bhagat,Sarma, C. R.,Krishna, R. R.,Singh, P. P.,Rao, C. Seshagiri
, p. 891 - 893 (2007/10/02)
A series of 4-(4-aryl/alkyl-5-alkoxyoxazol-2-yl)phenylacetic acids (4a-j) has been synthesised by the reaction of appropriately substituted glycinate hydrochlorides (1a-j) with α-cyano-p-toluoyl chloride followed by cyclization and hydrolysis of the resulting N-α-cyano-p-toluoylglycinates (2a-j).Esterification (CH2N2) of the oxazolylphenylacetic acids (4a-g) furnishes the corresponding methyl esters (5a-g).Several compounds in this series show moderate anti-inflammatory activity at one fifth of their LD50 dose in the carrageenin-induced rat paw oedema test.
