80589-80-6

Basic information

• Product Name: {4-[5-ethoxy-4-(1-methylethyl)-1,3-oxazol-2-yl]phenyl}acetic acid
• CAS NO: 80589-80-6
• Molecular Formula: C₁₆H₁₉NO₄
• Molecular Weight: 289.3264
• Mol File: 80589-80-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 461.1°C at 760 mmHg
• Flash Point: 232.7°C
• Density: 1.163g/cm³
• Vapor Pressure: 2.67E-09mmHg at 25°C
• Refractive Index: 1.538
• CAS DataBase Reference: {4-[5-ethoxy-4-(1-methylethyl)-1,3-oxazol-2-yl]phenyl}acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: {4-[5-ethoxy-4-(1-methylethyl)-1,3-oxazol-2-yl]phenyl}acetic acid(80589-80-6)
• EPA Substance Registry System: {4-[5-ethoxy-4-(1-methylethyl)-1,3-oxazol-2-yl]phenyl}acetic acid(80589-80-6)

Safety Data

• Hazardous Substances Data: 80589-80-6(Hazardous Substances Data)

Upstream product

• 80589-60-2 2-(4-Cyanomethyl-benzoylamino)-3-methyl-butyric acid ethyl ester 
• 80589-49-7 4-cyanomethylbenzoyl chloride 
• 50685-26-2 4-(cyanomethyl)benzoic acid 
• 80589-70-4 [4-(5-Ethoxy-4-isopropyl-oxazol-2-yl)-phenyl]-acetonitrile 

Relevant articles and documents

Anti-Inflammatory Agents: Part V - Synthesis of Some New 4-(4,5-Disubstituted-oxazol-2-yl)phenylacetic Acids and their Methyl Esters

A series of 4-(4-aryl/alkyl-5-alkoxyoxazol-2-yl)phenylacetic acids (4a-j) has been synthesised by the reaction of appropriately substituted glycinate hydrochlorides (1a-j) with α-cyano-p-toluoyl chloride followed by cyclization and hydrolysis of the resulting N-α-cyano-p-toluoylglycinates (2a-j).Esterification (CH2N2) of the oxazolylphenylacetic acids (4a-g) furnishes the corresponding methyl esters (5a-g).Several compounds in this series show moderate anti-inflammatory activity at one fifth of their LD50 dose in the carrageenin-induced rat paw oedema test.