Sigmamycin is a potent antitumor antibiotic that belongs to the enediyne family of compounds, characterized by a unique chemical structure that includes a conjugated enediyne system. It was first isolated from the bacterium Micromonospora inyoensis in the 1970s. Sigmamycin exhibits its cytotoxic effects by generating highly reactive diradical species upon reduction, which can cause DNA damage and lead to cell death. This mechanism of action makes it a significant compound in the field of cancer research and chemotherapy. The antibiotic is also known for its ability to inhibit the enzyme DNA topoisomerase II, which is crucial for DNA replication and transcription. Sigmamycin's potential as an anticancer agent is further highlighted by its ability to target rapidly dividing cells, a characteristic shared by many cancer cells. Despite its promising properties, the development of sigmamycin as a therapeutic agent has been limited due to its instability and toxicity. However, it remains an important subject of study for understanding the mechanisms of DNA damage and the development of new anticancer drugs.

8060-63-7

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Basic information
1. Product Name: sigmamycin
2. Synonyms:
3. CAS NO:8060-63-7
4. Molecular Formula: C35H61NO12.C22H24N2O8
5. Molecular Weight: 1132.3
6. EINECS: N/A
7. Product Categories: N/A
8. Mol File: 8060-63-7.mol
Chemical Properties
1. Melting Point: N/A
2. Boiling Point: 802.6°C at 760 mmHg
3. Flash Point: 439.2°C
4. Appearance: /
5. Density: N/A
6. Vapor Pressure: 8.49E-30mmHg at 25°C
7. Refractive Index: N/A
8. Storage Temp.: N/A
9. Solubility: N/A
10. CAS DataBase Reference: sigmamycin(CAS DataBase Reference)
11. NIST Chemistry Reference: sigmamycin(8060-63-7)
12. EPA Substance Registry System: sigmamycin(8060-63-7)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: N/A
4. WGK Germany:
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 8060-63-7(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 8060-63-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 8,0,6 and 0 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 8060-63:
(6*8)+(5*0)+(4*6)+(3*0)+(2*6)+(1*3)=87
87 % 10 = 7
So 8060-63-7 is a valid CAS Registry Number.

InChI:InChI=1/C35H61NO12.C22H24N2O8/c1-16-14-35(15-43-35)32(40)19(4)27(37)18(3)22(7)46-33(41)21(6)31(47-26-13-25(42-11)28(38)23(8)45-26)20(5)30(16)48-34-29(39)24(36(9)10)12-17(2)44-34;1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h16-31,34,37-39H,12-15H2,1-11H3;4-6,9-10,15,25-26,30-32H,7,23H2,1-3H3/b;20-14-/t16-,17-,18+,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29-,30+,31+,34+,35-;9-,10-,15-,21+,22-/m10/s1

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