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5-O-(beta-hydroxyethyl)diosmin, also known as 5-O-(2-hydroxyethyl)diosmin, is a semi-synthetic flavonoid derivative derived from Diosmin, a natural flavonoid found in various plants. 5-O-(beta-hydroxyethyl)diosmin is characterized by the addition of a hydroxyethyl group to the 5-O position of Diosmin, which enhances its pharmacological properties. It exhibits potent antioxidant, anti-inflammatory, and vasorelaxant effects, making it a potential candidate for the treatment of various vascular disorders, such as chronic venous insufficiency and microcirculation impairments. The chemical structure of 5-O-(beta-hydroxyethyl)diosmin consists of a flavone backbone with a hydroxyethyl group attached to the 5-O position, which contributes to its improved bioavailability and therapeutic efficacy compared to its parent compound, Diosmin.

80604-68-8

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80604-68-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 80604-68-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,6,0 and 4 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 80604-68:
(7*8)+(6*0)+(5*6)+(4*0)+(3*4)+(2*6)+(1*8)=118
118 % 10 = 8
So 80604-68-8 is a valid CAS Registry Number.

80604-68-8Relevant academic research and scientific papers

Besides sea tune process for the preparation of raw materials

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Paragraph 0024-0026, (2017/04/26)

The invention provides a process for preparing a hidrosmin bulk drug. The process comprises the following steps: (1) performing a synthesis reaction; (2) decolorizing a reacting liquid; (3) filtering the decolorizing liquid; (4) crystallizing the filterin

Synthesis of O-(β-hydroxyethyl) derivatives of diosmetin

Mosquera,Orjales

, p. 19 - 22 (2007/10/03)

Five O-(β-hydroxyethyl) derivatives (3, 4, 5, 6, 7) of diosmetin have been synthesized for the first time. Compounds 3 and 6 have been obtained by hydrolysis of 3'-O-(β-hydroxyethyl)- and 3′,5-di-O-(β-hydroxyethyl)diosmin, respectively. Compound 4 has been prepared from diosmetin, after protecting the hydroxyls at C-7 and C-3′, using ethylene oxide or ethyl chloroacetate and sodium borohydride, followed by removal of the protective groups. Compounds 5 and 7 have been prepared by the reaction of diosmetin (8) and 6 with ethylene chlorohydrin, respectively.

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