80610-03-3

Upstream product

• 1123-49-5 3,5-dimethyl-4-nitroisoxazole 
• 635-93-8 5-chlorosalicyclaldehyde 

Downstream Products

• 80610-08-8 Acetic acid 4-chloro-2-[1-(3-methyl-4-nitro-isoxazol-5-ylmethyl)-3-oxo-butyl]-phenyl ester 
• 114650-04-3 Acetic acid 4-chloro-2-[1-(3-methyl-4-nitro-isoxazol-5-ylmethyl)-3-oxo-3-phenyl-propyl]-phenyl ester 
• 80610-13-5 4-Chloro-2-(3,5-dimethyl-7,8-dihydro-6H-isoxazolo[4,5-b]azepin-7-yl)-phenol 

Relevant academic research and scientific papers

Synthesis of 4H-chromene-isoxazole hybrids via ortho-hydroxy directing cyclization of isoxazole-styrenes and Michael addition of imino-chromenes in aqueous medium

A green, efficient, and one-pot method synthesis of functionalized 4H-chromene-isoxazole hybrids is reported via o-hydroxy group directing cyclization of isoxazole-styrenes and Michael addition of 3,5-dimethyl-4-nitroisoxazole on 2-imino-2H-chromene-3-carbonitrile (independent methods). The developed methodology was further extended for nitromethane, malononitrile, and alkylcyanoacetates as Michael donors.

Fused Heterocycles. IV. Synthesis of 7-(o-Hydroxyphenyl)-3,5-dimethyl-7,8-dihydro-6H-isoxazoloazepines

Michael addition of acetylacetone to 3-methyl-4-nitro-5-(o-hydroxystyryl)isoxazoles gives 4-(o-acetoxyphenyl)-5-(3-methyl-4-nitro-5-isoxazoyl)-2-pentanones (4).Reductive cyclization of 4 with tin(II) chloride and concentrated hydrochloric acid leads to 7-