80615-39-0

Basic information

• Product Name: (2-Hydroxy-4-methyl-phenyl)-phosphonic acid diethyl ester
• Synonyms: (2-Hydroxy-4-methyl-phenyl)-phosphonic acid diethyl ester
• CAS NO: 80615-39-0
• Molecular Weight: 244.227
• Mol File: 80615-39-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2-Hydroxy-4-methyl-phenyl)-phosphonic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Hydroxy-4-methyl-phenyl)-phosphonic acid diethyl ester(80615-39-0)
• EPA Substance Registry System: (2-Hydroxy-4-methyl-phenyl)-phosphonic acid diethyl ester(80615-39-0)

Safety Data

• Hazardous Substances Data: 80615-39-0(Hazardous Substances Data)

Upstream product

• 14143-01-2 diethyl m-methylphenyl phosphate 
• 108-39-4 3-methyl-phenol 

Downstream Products

• 129529-19-7 2-(Diethyl-phosphinoyl)-5-methyl-phenol 

Relevant articles and documents

Enantioselective and Regioselective Hydroetherification of Alkynes by Gold-Catalyzed Desymmetrization of Prochiral Phenols with P-Stereogenic Centers

The gold(I)-catalyzed enantioselective hydroetherification of alkynes was achieved via desymmetrization of prochiral bisphenols bearing P-stereogenic centers. (S)-DTBM-Segphos(AuCl)2/AgNTf2 proved to be a highly efficient catalyst system for this transformation, affording P-chiral cyclic phosphine oxides in good yields with high enantioselectivities (with up to 99% ee). The same catalyst system allowed for the enantioselective desymmetrization of dialkynes. Synthetic transformations of the cyclization products afforded other P-chiral molecules with high enantiospecificity.

AN EFFICIENT SYNTHESIS OF 2-HYDROXYPHENYLPHOSPHONATES

The high yield conversion of phenols into diethyl 2-hydroxyphenylphosphonates via base catalyzed rearrangement of diethyl phenyl phosphates has been achieved.