80632-52-6

Basic information

• Product Name: L-Leucine,O-sulfo-L-tyrosylglycylglycyl-L-phenylalanyl-
• Synonyms: L-Leucine,N-[N-[N-[N-(O-sulfo-L-tyrosyl)glycyl]glycyl]-L-phenylalanyl]-;Leu-Enkephalin (sulfated);H-Tyr(SO3H)-Gly-Gly-Phe-Leu-OH
• CAS NO: 80632-52-6
• Molecular Formula: C₂₈H₃₇N₅O₁₀S
• Molecular Weight: 635.6859
• Mol File: 80632-52-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.371 g/cm³
• Refractive Index: 1.596
• Storage Temp.: -15°C
• PKA: -4.14±0.18(Predicted)
• CAS DataBase Reference: L-Leucine,O-sulfo-L-tyrosylglycylglycyl-L-phenylalanyl-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine,O-sulfo-L-tyrosylglycylglycyl-L-phenylalanyl-(80632-52-6)
• EPA Substance Registry System: L-Leucine,O-sulfo-L-tyrosylglycylglycyl-L-phenylalanyl-(80632-52-6)

Safety Data

• Hazardous Substances Data: 80632-52-6(Hazardous Substances Data)

Usage

General Description

"L-Leucine, O-sulfo-L-tyrosylglycylglycyl-L-phenylalanyl-" refers to a specific type of chemical compound that is composed of amino acids such as L-Leucine and L-Phenylalanyl. The "O-sulfo" portion suggests a sulfate group is attached to a tyrosine amino acid in the compound, indicating its sulfated form. L-Leucine,O-sulfo-L-tyrosylglycylglycyl-L-phenylalanyl- may play a role in various biochemical reactions and functions in the body due to the functions of its component amino acids. For instance, L-Leucine is important in protein synthesis and metabolic regulation, while L-Phenylalanyl is necessary for the production of other amino acids and biologically active compounds. However, the specific context and role of this complex compound is not specified and would likely depend on further research or the context in which it is being studied.

InChI:InChI=1/C28H37N5O10S/c1-17(2)12-23(28(38)39)33-27(37)22(14-18-6-4-3-5-7-18)32-25(35)16-30-24(34)15-31-26(36)21(29)13-19-8-10-20(11-9-19)43-44(40,41)42/h3-11,17,21-23H,12-16,29H2,1-2H3,(H,30,34)(H,31,36)(H,32,35)(H,33,37)(H,38,39)(H,40,41,42)/t21-,22-,23-/m0/s1

Upstream product

• 1080-04-2 p-nitrophenyl sulfate 
• 58822-25-6 Leu-enkephalin 
• 69729-16-4 N-benzyloxycarbonyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucine benzyl ester 
• 98908-58-8 Z(OMe)-Gly-Gly-Phe-Leu-OBzl 
• 69729-07-3 H-Gly-Gly-Phe-Leu-OBzl 
• 69729-15-3 N-Carbobenzoxy-L-tyrosyl azide 
• 16679-95-1 benzyl (S)-(1-hydrazinyl-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate 
• 130245-55-5 Z-Tyr(SO₃H)-Gly-Gly-Phe-Leu-OBzl 

Relevant articles and documents

Sulfation of various alcoholic groups by an arylsulfate sulfotransferase from desulfitobacterium hafniense and synthesis of estradiol sulfate

Bacterial arylsulfate sulfotransferases (AST) are enzymes that catalyse the transfer of a sulfate group from p-nitrophenyl sulfate (p-NPS) to a phenolic acceptor molecule. By screening of the NCBI protein database a gene coding for an AST was found in Desulfitobacterium hafniense. After expression the enzyme was purified and characterised. This AST efficiently sulfates various acceptor molecules (estrone, estradiol, enkephalin and non-phenolic alcohols) using p-NPS as sulfate donor. The purified AST has a pH optimum of 9.6, it is stable in the presence of 10% of DMSO, and depending on the conditions it has a melting temperature of up to 47°C. Surprisingly, and in great contrast to all other known bacterial ASTs, this enzyme was able to use a variety of non-phenolic alcohols as sulfate acceptor. Because of these properties, this unique enzyme is a promising tool for biotransformation processes, providing a green and simple method to specifically sulfate compounds without need for functional group protection.