80635-42-3

Upstream product

• 98-80-6 phenylboronic acid 
• 3678-62-4 2-chloro-4-picoline 
• 1003-67-4 4-methylpyridine-1-oxide 

Downstream Products

• 80635-45-6 4-Methyl-6-phenyl-pyridine-2-carbonitrile 
• 80635-46-7 4-methyl-6-phenyl-2-pyridinecarboxylic acid 
• 80635-47-8 4-Methyl-6-phenyl-pyridine-2-carbonyl chloride 
• 80635-48-9 4-Methyl-6-phenyl-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide 

Relevant academic research and scientific papers

Pd(II)-catalyzed monoarylation of 2-phenylpyridine N-oxide with iodobenzene in water

A Pd(II)-catalyzed activation and arylation of C(sp2)–H bond directed by pyridine N-oxide in water is achieved with high regioselectivity to form monoarylated products in yields up to 91%. The wide substrate scope highlights the flexibility of the catalyst. The reaction mechanism was proposed and the application of this method was taken as an example by the synthesis of COX-2 inhibitor analog.

Palladium-catalyzed direct C-H arylation of pyridine N-oxides with potassium aryl- and heteroaryltrifluoroborates

An efficient ligand-free Pd(OAc)2-catalyzed selective arylation of pyridine N-oxides using potassium (hetero)aryltrifluoroborates as coupling partners via C-H bond activation was achieved in the presence of TBAI. This approach has a broad subst