80637-22-5

Basic information

• Product Name: (3-Chloro-propylsulfanylethynyl)-benzene
• Synonyms: (3-Chloro-propylsulfanylethynyl)-benzene
• CAS NO: 80637-22-5
• Molecular Weight: 210.727
• Mol File: 80637-22-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3-Chloro-propylsulfanylethynyl)-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (3-Chloro-propylsulfanylethynyl)-benzene(80637-22-5)
• EPA Substance Registry System: (3-Chloro-propylsulfanylethynyl)-benzene(80637-22-5)

Safety Data

• Hazardous Substances Data: 80637-22-5(Hazardous Substances Data)

Upstream product

• 53310-50-2 3-chloropropyl thiocyanate 
• 536-74-3 phenylacetylene 

Downstream Products

• 60973-46-8 2-phenyl-6,7-dihydro-5H-1,4-dithiepine 

Relevant articles and documents

Synthesis of six- and seven-membered heterocycles by reaction of 1-(2-chloroethylthio)-1-alkynes and 1-(3-chloropropylthio)-1-alkynes with alkali metal sulfide, selenide and telluride

Reaction of RCC-S-CH2CH2Cl (1, R=alkyl) compounds with dilithium disulfide (Li2S2) in ethanol gives 3-alkyl-5,6-dihydro-1,4-dithiins (2, n=2, X=S).With the alkali monosulfide, M2S, dehydrochlorination to (vinylthio)alkynes RCC-S-CH=CH2 (3) predominates.Interaction between 1, n=2, and M2Se or M2Te (M=Li or Na) in liquid ammonia gives rise to dehydrochlorination as well as to attack on chlorine with intermediate formation of alkynethiolates RCC-S- (4); if this reaction is carried out in ammonia-free ethanol, the desired 5,6-dihydro-1,4-thiaselenins and -thiatellurins (2, n=2, X=Se or Te) are, in some cases, obtained.The chloro sulfides RCC-S-(CH2)3Cl (1, R=alkyl or phenyl) with alkali metal sulfide, selenide and telluride yield respectively 3-alkyl- or 3-aryl-6,7-dihydro-5H-1,4-dithiepins, the corresponding 6,7-dihydro-5H-1,4-thiaselenepins and 6,7-dihydro-5H-thiatellurepins (2, n=3).When R in the starting compounds 2 is a Me3Si group, the unsubstituted compounds 2 (n=3, R=H) are formed.