80638-83-1Relevant academic research and scientific papers
Synthesis of (+)-varitriol analogues via novel and versatile building blocks based on julia olefination
Senthilmnrugan, Annamalai,Aidhen, Indrapal Singh
experimental part, p. 555 - 564 (2010/04/24)
The synthesis of (+)-varitriol (1) analogues was achieved through, the use of Julia olefination. The potential anticancer properties of 1 coupled with, our interest in developing building blocks that enable olefin formation under the Julia protocol constitute the basis of our research project. Efforts are aimed at the synthesis of building blocks 2 and 3 and to explore their use towards the synthesis of (+)-varit:riol analogues. Herein, we would, like to present the synthesis of building block 3 and its ability to react with variety of substituted aromatic-, heterocyclic- and carbohydrate-derived aldehydes to yield alkene 6 in moderate to good yields with E as the major isomer. The successful, coupling of 2 with (furanoside moieties) aldehydes 5k, 5m and 5n in particular and the obtainment of compound 23 reflect the promise associated with the new strategy.
Alkenyl-copper derivatives 19. Synthesis of conjugated dienes and styrenes by cuopling of alkenyl cuprates with alkenyl and aryl halides
Jabri, N.,Alexakis, A.,Normant, J. F.
, p. 321 - 331 (2007/10/02)
Z dialkenylcuprates obtained by carbometallation of acetylene couple easily with alkenylhalides and iodoarenes in the presence of ZnBr2 and a catalytic amount of NiL4 or Pd0L4 to afford high yields of conjugated dienes and styrenes with very high stereoselectivity.Such pure dienes are often encountered in insect sex pheromones.
ORGANO-CUIVREUX VINYLIQUES 14. ARYLATION DES CUPRATES VINYLIQUES
Jabri, N.,Alexakis, A.,Normant, J. F.
, p. 3851 - 3852 (2007/10/02)
Z dialkenyl cuprates couple easily with iodo arenes in the presence of ZnBr2 and a catalytic amount of Pd(PPh3)4.
