80650-84-6Relevant academic research and scientific papers
Synthesis of a substituted benzazepin-2-one dihydrate
Boini, Sathish K.,Vaid, Radhe K.,Moder, Kenneth P.,Mitchell, David
scheme or table, p. 1983 - 1986 (2010/01/13)
Synthesis of the title compound was accomplished via coupling of (S)-alaninyl-(S)-1-amino-3-methyl-4,5,6,7-tetrahydro-2H-3-benzazepin-2-one with the activated trimethylsilyl ester of (S)-2-trimethylsilyloxy-3-methylbutyric acid, followed by deprotection a
Modular evolution of a chiral auxiliary for the 1,3-dipolar cycloaddition of isomuenchnones with vinyl ethers.
Savinov, Sergey N,Austin, David J
, p. 1415 - 1418 (2007/10/03)
[reaction: see text]. The 1,3-dipolar cycloaddition reaction has long been recognized as a powerful methodology in organic synthesis. More recently, this reaction has become a popular manifold for the construction of chemical diversity. Herein, we report the development of a chiral template for the facially selective cycloaddition of isomuenchnones, a common class of 1,3-dipoles. The modular format of the asymmetric unit allowed a systematic optimization of selectivity. In addition, the chiral auxiliary was removed through an unusually facile ester aminolysis.
