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Maleimide, 4-hydroxy-3-(2-(pyridyl)-4-thiazolyl)-, is a versatile chemical compound that features a maleimide group and a hydroxy-thiazolyl-pyridyl moiety. Maleimide, 4-hydroxy-3-(2-(pyridyl)-4-thiazolyl)is known for its ability to form stable covalent bonds with thiol-containing biomolecules, making it a valuable asset in the fields of chemical biology and bioconjugation. The maleimide group's reactivity with thiol groups on proteins, peptides, and other biomolecules results in the formation of a stable thioether bond, which is instrumental in the labeling and modification of these biomolecules. Furthermore, the 4-hydroxy-3-(2-(pyridyl)-4-thiazolyl)component of the compound offers additional functional groups that facilitate further chemical modifications, enhancing its utility as a building block for the synthesis of bioconjugates and drug delivery systems.

80653-76-5

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80653-76-5 Usage

Uses

Used in Chemical Biology:
Maleimide, 4-hydroxy-3-(2-(pyridyl)-4-thiazolyl)is used as a reactive intermediate for the covalent attachment of biomolecules, particularly in the labeling and modification of proteins and peptides. Its ability to form stable thioether bonds with thiol groups makes it an ideal candidate for this application.
Used in Bioconjugation Applications:
Maleimide, 4-hydroxy-3-(2-(pyridyl)-4-thiazolyl)serves as a key component in the synthesis of bioconjugates, where it enables the stable linkage of biologically active molecules to other entities, such as nanoparticles or other biomolecules, for various research and therapeutic purposes.
Used in Drug Delivery Systems:
Maleimide, 4-hydroxy-3-(2-(pyridyl)-4-thiazolyl)is utilized as a building block in the development of drug delivery systems. Its functional groups allow for the attachment of therapeutic agents to drug carriers, improving the targeting and delivery of drugs to specific cells or tissues.
Used in the Synthesis of Bioconjugates:
Maleimide, 4-hydroxy-3-(2-(pyridyl)-4-thiazolyl)is employed as a versatile building block in the synthesis of bioconjugates, which are essential for various applications, including diagnostics, therapeutics, and the study of molecular interactions. Its unique structure allows for the creation of stable and functional bioconjugates with tailored properties.

Check Digit Verification of cas no

The CAS Registry Mumber 80653-76-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,6,5 and 3 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 80653-76:
(7*8)+(6*0)+(5*6)+(4*5)+(3*3)+(2*7)+(1*6)=135
135 % 10 = 5
So 80653-76-5 is a valid CAS Registry Number.
InChI:InChI=1/C12H7N3O3S/c16-9-8(10(17)15-11(9)18)7-5-19-12(14-7)6-1-3-13-4-2-6/h1-5H,(H2,15,16,17,18)

80653-76-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-hydroxy-4-(2-pyridin-4-yl-1,3-thiazol-4-yl)pyrrole-2,5-dione

1.2 Other means of identification

Product number -
Other names 1H-Pyrrole-2,5-dione,4-hydroxy-3-(2-(pyridyl)-4-thiazolyl)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:80653-76-5 SDS

80653-76-5Downstream Products

80653-76-5Relevant academic research and scientific papers

4-(Pyridyl, piperazinyl and thiazolyl substituted thiazolyl)-3-hydroxy-3-pyrroline-2,5-diones

-

, (2008/06/13)

Novel 4-(substituted thiazolyl)-3-hydroxy-3-pyrroline-2,5-diones are disclosed which inhibit glycolic acid oxidase and thus are useful in the treatment and prevention of calcium oxalate renal lithiasis.

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