80658-16-8Relevant academic research and scientific papers
Antiplasmodial benzophenones from the trunk latex of Moronobea coccinea (Clusiaceae)
Marti, Guillaume,Eparvier, Véronique,Moretti, Christian,Susplugas, Sophie,Prado, Soizic,Grellier, Philippe,Retailleau, Pascal,Guéritte, Fran?oise,Litaudon, Marc
, p. 75 - 85 (2009)
In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The methanol extract obtained from the latex of
Xanthochymol and Isoxanthochymol, Two Novel Polyisoprenylated Benzophenones from Gracinia xanthochymus
Rao, A. V. Rama,Ventkatswamy, G.,Yemul, S. S.
, p. 627 - 633 (2007/10/02)
Two optically active polyprenylated benzophenone derivates, (+)-xanthochymol and (+)-isoxanthochymol have been isolated from the fruits of Gracinia xanthochymus (fam.: Guttiferae).Both these compounds possess the same molecular formula, C38H50O6, and have many common features.Xanthochymol has a free enolic hydroxyl group which forms a part of the chroman ring in isoxanthochymol.Chemical and spectral evidence clearly indicate that both these compounds are derived from maclurin (2,4,6,3',5'-pentahydroxybenzophenone) in which the acetate derived phloroglucinol ringbecomes the target of attack by five "active isoprene" groups.Although, a partial structure has been suggested, the final structure for (+)-isoxanthochymol (V) has been established by X-ray analysis.Spectral evidence including 13C NMR data leads to structure (VIII) for (+)-xanthochymol which has also been arrived at independently by Blount and Williams . (+)-Xanthochymol has been smoothly converted to (+)-isoxanthochymol by acid-catalysed reactions.Bronianone isolated earlier by Ollis et al., from G. hambroniana has the same basic skeleton as xanthochymol and can be represented as X instead of having a bicyclooctene system.
