806596-29-2Relevant academic research and scientific papers
Preparation method of (S)-4-chloro-2-aminobutyrate
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Paragraph 0038; 0039, (2019/03/08)
The invention relates to the field of agricultural herbicides. In order to solve the problem of a relatively low yield, the invention provides a preparation method of (S)-4-chloro-2-aminobutyrate. Thetechnical scheme is as follows: the preparation method comprises the following steps: carrying out ring-opening alcoholysis on (S)-2-amino butyrolactone under catalysis of an acid to obtain corresponding S-homoserine ester; and then carrying out chlorination by a chlorination agent to obtain a target product, wherein the reaction formula is as shown in the description. The butyrolactone structurecan achieve synchronous ring opening and synchronous esterification in a system of alcohol under the catalysis of a strong acid, and chemical equilibrium is continuously promoted to move forward to obtain the (S)-4-chloro-2-aminobutyrate with a high yield.
