80662-85-7Relevant academic research and scientific papers
Hydroboration-Carbon Monoxide Insertion of Bis-Olefinic Amine Derivatives. Synthesis of δ-Coniceine, Pyrrolizidine, (+/-)-Heliotridane, and (+/-)-Pseudoheliotridane
Garst, Michael E.,Bonfiglio, John N,Marks, Jeffrey
, p. 1494 - 1500 (2007/10/02)
The hydroboration-carbon monoxide insertion of several bis-olefinic derivatives has provided facile preparations of N-(carbomethoxy)-5-azacyclooctanone (6), N-(carbobenzyloxy)-5-azacyclooctanone (9), and N-(carbobenzyloxy)-5-cyclononanone (18).Of the hydroboration protocols examined, thexylborane-cyanidation proved to be the most useful.Reductive ring closure of 9 and of 18 gave 26 and 27, respectively.Methylation of 9 followed by reduction afforded 29 and 30.
