80663-46-3Relevant academic research and scientific papers
On the antibiotic activity of oxazolomycin
Bagwell, Claire L.,Moloney, Mark G.,Thompson, Amber L.
, p. 4081 - 4086 (2008)
Structural analysis of oxazolomycin and simpler fragments containing a common 3-hydroxy-2,2-dimethylpropanamide moiety has indicated that a U-shaped conformation is preferred, in some cases stabilised by hydrogen bonding between the N-H and O-H residues, as shown by a combination of molecular modelling, NMR spectroscopic and single crystal X-ray analysis. A direct synthesis of this unit has been established via the opening of β-lactones by a range of amines, and their antibacterial activity been shown to vary with the hydrophobic character of the substituents.
