8068-28-8

Basic information

• Product Name: COLISTIN METHANESULFONATE SODIUM SALT
• Synonyms: COLIMYCIN SODIUM METHANESULFONATE;COLISTIN METHANESULFONATE SODIUM SALT;COLISTIN SODIUM METHANESULFONATE;(METHANESULFONIC ACID DERIVATIVE OF POLYMYXIN E) SODIUM SALT;POLYMYXIN E SODIUM METHANESULFONATE;colimycinm;colistinat;colistinmethanesulfonicacid,sodiumsalt
• CAS NO: 8068-28-8
• Molecular Formula: C58H105N16Na5O28S5
• Molecular Weight: 1749.81855
• EINECS: 232-516-9
• Product Categories: COLOMYCIN
• Mol File: 8068-28-8.mol
• Article Data: 0

Chemical Properties

• Appearance: white to faintly beige/
• Storage Temp.: 2-8°C
• Solubility: H2O: soluble10mg/mL
• Water Solubility: Freely soluble in water
• Merck: 13,2503
• CAS DataBase Reference: COLISTIN METHANESULFONATE SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: COLISTIN METHANESULFONATE SODIUM SALT(8068-28-8)
• EPA Substance Registry System: COLISTIN METHANESULFONATE SODIUM SALT(8068-28-8)

Safety Data

• RIDADR: 3249
• WGK Germany: 2
• RTECS: GH1650000
• F: 3
• TSCA: Yes
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 8068-28-8(Hazardous Substances Data)

Usage

Chemical Properties

White or almost white, hygroscopic powder.

Uses

Colistin sodium methanesulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination. It is used to study effective treatments of P. aeruginosa infections in cystic fibrosis patients and to study the pharmacokinetics and BAL concentration of colistin in critically ill patients.

Definition

ChEBI: A mixture where R = H or Me. Colistin in which each of the primary amino groups is converted to the corresponding aminomethanesulfonic acid sodium salt, commonly by the action of formaldehyde followed by sodium bisulfite. A polymyxin antibiotic derivative, it is used in the treatment of severe infections, particularly of multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii.

Brand name

Coly-Mycin (Monarch).

Biological Activity

colistin methanesulfonate is an inactive prodrug of colistin (also known as polymyxin e), which is an antibiotic with effect against most gram-negative bacteria, but also causes nephro- and neurotoxicity [1]. colistin is produced by certain strains of the bacteria paenibacillus polymyxa, and belongs to the class of polypeptide antibiotics known as polymyxins.in vitro: studying the time-kill kinetics of colistin methanesulfonate against a type culture of pseudomonas aeruginosa found that 8.0 or 32 mg/l colistin methanesulfonate began killing at approximately 90 or 30 min, and the mean auc0-240 values were 186.3±6.0 and 90.4±4.1, respectively [2]. besides, by investigation among mucoid and nonmucoid strains of pseudomonas aeruginosa isolated from patients with cystic fibrosis, colistin methanesulfonate was found to require a concentration of 16 times the mic to achieve complete killing within 24 h [3].

Safety Profile

Human poison by intramuscular route. Experimental poison by intramuscular, intraperitoneal, subcutaneous, and intravenous routes. Mildly toxic by ingestion. An experimental teratogen. Human systemic effects by intramuscular route: convulsions or effect on seizure threshold, change in motor activity, change in lrldney tubules, and urine volume decrease or anuria. Experimental reproductive effects. Used as an antibiotic. When heated to decomposition it emits very toxic fumes of NOx, SOx, and NazO

references

[1] nation r l, li j. colistin in the 21st century.[j]. current opinion in infectious diseases, 2009, 22(6): 535-543.[2] bergen p j, li j, rayner c r, et al. colistin methanesulfonate is an inactive prodrug of colistin against pseudomonas aeruginosa.[j]. antimicrobial agents and chemotherapy, 2006, 50(6): 1953-1958.[3] li j, turnidge j d, milne r w, et al. in vitro pharmacodynamic properties of colistin and colistin methanesulfonate against pseudomonas aeruginosaisolates from patients with cystic fibrosis[j]. antimicrobial agents and chemotherapy, 2001, 45(3): 781-785.