Colistimethate sodium, also known as Colistin methanesulfonate or Coly-Mycin M, is a highly water-soluble compound derived from colistin, an antibiotic. It is created by attaching a methanesulfonate radical to the terminal amino groups of the α-aminobutyric acid fragment in colistin, forming a sodium salt. This modification makes it suitable for injection and less toxic compared to polymyxin B.
8068-37-9
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Basic information
- Product Name: COLISTIMETHATE SODIUM
- Synonyms: COLISTIMETHATE SODIUM;ColistinSulphomethate;Colimicina;Colimyscine
- CAS NO:8068-37-9
- Molecular Formula: C58H105N16Na5O28S5
- Molecular Weight: 1749.8185
- EINECS: 232-516-9;
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: COLISTIMETHATE SODIUM(CAS DataBase Reference)
- NIST Chemistry Reference: COLISTIMETHATE SODIUM(8068-37-9)
- EPA Substance Registry System: COLISTIMETHATE SODIUM(8068-37-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 8068-37-9(Hazardous Substances Data)
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8068-37-9 Usage
Uses
Used in Pharmaceutical Industry:Colistimethate sodium is used as an antibacterial agent for treating infections caused by gram-negative bacteria, particularly in cases where other antibiotics are ineffective. It is effective against a wide range of bacteria, including Pseudomonas aeruginosa and Acinetobacter baumannii.
Used in Hospital Settings:
Colistimethate sodium is used as a last-resort antibiotic for treating severe infections in hospitalized patients when other treatment options have failed. Its low toxicity and lack of cross-resistance with common broad-spectrum antibiotics make it a valuable option in these situations.
Used in Combating Antibiotic Resistance:
Colistimethate sodium is used as a tool in the fight against antibiotic resistance, as it does not readily induce the development of resistant strains of microorganisms. This property is crucial in the ongoing battle against the rise of antibiotic-resistant infections.
Check Digit Verification of cas no
The CAS Registry Mumber 8068-37-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 8,0,6 and 8 respectively; the second part has 2 digits, 3 and 7 respectively.Calculate Digit Verification of CAS Registry Number 8068-37:
(6*8)+(5*0)+(4*6)+(3*8)+(2*3)+(1*7)=109
109 % 10 = 9
So 8068-37-9 is a valid CAS Registry Number.
InChI:InChI=1/C58H110N16O28S5.5Na/c1-9-35(6)12-10-11-13-46(77)65-38(14-20-59-28-103(88,89)90)53(82)74-48(37(8)76)58(87)70-41(17-23-62-31-106(97,98)99)50(79)68-43-19-25-64-57(86)47(36(7)75)73-54(83)42(18-24-63-32-107(100,101)102)67-49(78)39(15-21-60-29-104(91,92)93)69-55(84)44(26-33(2)3)72-56(85)45(27-34(4)5)71-52(81)40(66-51(43)80)16-22-61-30-105(94,95)96;;;;;/h33-45,47-48,59-63,75-76H,9-32H2,1-8H3,(H,64,86)(H,65,77)(H,66,80)(H,67,78)(H,68,79)(H,69,84)(H,70,87)(H,71,81)(H,72,85)(H,73,83)(H,74,82)(H,88,89,90)(H,91,92,93)(H,94,95,96)(H,97,98,99)(H,100,101,102);;;;;/q;5*+1/p-5
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COLISTIMETHATE SODIUM
