80680-86-0Relevant academic research and scientific papers
C-NOR-D-HOMO-CARDENOLIDE GLYCOSIDES FROM THEVETIA NERIIFOLIA
Abe, Fumiko,Yamauchi, Tatsuo,Nohara, Toshihiro
, p. 251 - 254 (2007/10/02)
Along with known digitoxigenin α-L-thevetoside and α-L-acofrioside, the corresponding glycosides of a C-nor-D-homocardenolide were isolated from the air-dried leaves of Thevetia neriifolia and their structures determined by spectral and chemical methods.Triosides of the C-nor-D-homo-cardenolide were obtained from the methanol extract of the fresh leaves. Key Word Index - Thevetia neriifolia; Apocynaceae; leaves; cardenolide; C-nor-D-homo-cardenolide; thevetioside.
Elimination Reactions and Rearrangement of 14β-Hydroxy-12-sulfonyloxy Steroids.
Hammann, Peter E.,Habermehl, Gerhard G.
, p. 149 - 156 (2007/10/02)
Elimination of 12α- or 12β-(methylsulfonyloxy)-14β-hydroxy steroids proceeds under rearrangement of the steroid nucleus.From the 12α-sulfonyloxy compounds of 19 the (12βH)-14(13->12)abeo-13(18)-ene steroid 21 is obtained, whereas the 14β-hydroxy-(12βH)-17(13->12)abeo-13(18)ene compounds 14, 20 result from the 12β-methylsulfonyloxy derivatives of the steroids 13, 18.Structures were determined by means of 2D-NMR analyses and decoupling experiments.The theoretical explanation of this rearrangement leads to the possibility of an elimination of the 12α-methylsulfonyloxy group to yield the Δ11-alkene (28).This is possible by steric fixation of the migrating C-atoms at positions 14 and 17 in the 20,14β-lactone (26, 27).
14β-HYDROXY STEROIDS-III. SYNTHESIS OF DIGOXIGENIN FROM DEOXYCHOLIC ACID
Welzel, Peter,Stein, Hermann
, p. 3385 - 3388 (2007/10/02)
A new synthetic approach to cardenolides is discussed which employs singlet oxygen addition to dienol ethers and an intramolecular Prins reaction.
